biologia plantarum

International journal on Plant Life established by Bohumil Němec in 1959

Biologia plantarum 61:417-426, 2017 | DOI: 10.1007/s10535-017-0706-y

Cytosolic GAPDH: a key mediator in redox signal transduction in plants

S. S. Yang1,*, Q. H. Zhai1
1 College of Life Sciences, Northwest A&F University, Yangling, Shaanxi, P.R. China

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) serves not only as a key enzyme in glycolysis, but also as a multifunctional protein in other biological processes, especially in response to abiotic stresses in plants. Cytosolic GAPDH (GAPC) is a typical redox protein with selected catalytic cysteine, which undergoes reversible redox post-translational modifications (RPTMs) on its thiol group by reacting with hydrogen peroxide and nitric oxide related species. Moreover, the modified GAPC may interact with certain signal transmitters such as phosphatidic acid, phospholipase D, and osmotic stress-activated protein kinase. All these observations suggest that GAPC serve as a key mediator in redox signal transduction in plants. In this review, we provide an up-to-date insight into molecular mechanisms after H2O2- and NO-dependent oxidation of GAPC. We also discuss GAPC catalytic functions and potential functions as a modified protein by RPTMs.

Keywords: abiotic stresses; cysteine modification; glycolysis; hydrogen peroxide; nitric oxide; post-translational modifications
Subjects: glyceraldehyde-3-phosphate dehydrogenase; signal transduction; glycolysis; hydrogen peroxide; nitric oxide; post-translational modifications; cystein modification

Received: January 15, 2016; Revised: September 16, 2016; Accepted: October 13, 2016; Published: September 1, 2017  Show citation

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Yang, S.S., & Zhai, Q.H. (2017). Cytosolic GAPDH: a key mediator in redox signal transduction in plants. Biologia plantarum, 61(3), 417-426. doi: 10.1007/s10535-017-0706-y
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