Diarrheagenic Escherichia coli infections among the children of Andaman Islands with special reference to pathotype distribution and clinical profile

Raghavan P. Ramya; Subarna Roy; Ramanathan Thamizhmani; Attayur Purushothaman Sugunan

doi:10.1016/j.jegh.2017.07.003

<Previous Article In Issue

Volume 7, Issue 4, December 2017, Pages 305 - 308

Diarrheagenic Escherichia coli infections among the children of Andaman Islands with special reference to pathotype distribution and clinical profile

Authors

Raghavan P. Ramya^a, Subarna Roy^b, Ramanathan Thamizhmani^a, Attayur Purushothaman Sugunan^c^{, *}^,apsugunan@gmail.com

^aDept. Microbiology, Regional Medical Research Centre, Port Blair, Andaman and Nicobar Islands, India

^bDept. Microbiology, National Institute of Traditional Medicine, Belgaum, Karnataka, India

^cDept. Epidemiology, Regional Medical Research Centre, Port Blair, Andaman and Nicobar Islands, India

^*Corresponding author at: Regional Medical Research Centre (ICMR), Port Blair, Dollygunj, Port Blair Andaman & Nicobar Islands 744101, India.

Corresponding Author

Attayur Purushothaman Sugunanapsugunan@gmail.com

Received 26 December 2016, Revised 12 July 2017, Accepted 21 July 2017, Available Online 31 July 2017.

DOI: 10.1016/j.jegh.2017.07.003 How to use a DOI?
Keywords: Diarrhoeagenic E.coli; Andaman Islands
Abstract: Diarrhoeagenic E. coli (DEC) is one of the most common causes of diarrhoeal death in children less than five years globally. It is responsible for 30%–40% of all diarrhoeal episodes in developing countries. It is estimated that 0.12 million children died of diarrhoea caused by DEC in 2011 globally. There is no baseline data on the occurrence of DEC diarrhoea in Andaman Islands, the remote islands of India. The study is particularly important as these strains are the emerging enteric pathogen in both developed and developing countries. DEC was screened from E. coli isolates obtained from diarrhoeal stool samples by multiplex PCR with specific primers using stasndard protocols. During the study period, among the 1394 stool samples collected, 95 (6.82%) patients were found infected with DEC. Of the 97 isolates from 95 patients, 68 (70.1%) were EAEC, 19 (19.6%) were EPEC and 10 (10.3%) were ETEC. Of the 19 EPEC isolates, 63.2% were atypical EPEC which is the emerging enteric pathogen among the children in developing as well as developed countries. More than 80% of the patients had watery diarrhoea and 6% of them had invasive diarrhoea. Persistent diarrhoea was also found in three infected children. This study documents the occurrence and type of DEC diarrhoea in Andaman Islands first time and highlights the significant proportions of E. coli diarrhoea being caused by EAEC and atypical EPEC strains.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Download article (PDF)
View full text (HTML)

<Previous Article In Issue

Journal: Journal of Epidemiology and Global Health
Volume-Issue: 7 - 4
Pages: 305 - 308
Publication Date: 2017/07/31
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2017.07.003 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Cite this article

ris enw bib

TY  - JOUR
AU  - Raghavan P. Ramya
AU  - Subarna Roy
AU  - Ramanathan Thamizhmani
AU  - Attayur Purushothaman Sugunan
PY  - 2017
DA  - 2017/07/31
TI  - Diarrheagenic Escherichia coli infections among the children of Andaman Islands with special reference to pathotype distribution and clinical profile
JO  - Journal of Epidemiology and Global Health
SP  - 305
EP  - 308
VL  - 7
IS  - 4
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2017.07.003
DO  - 10.1016/j.jegh.2017.07.003
ID  - Ramya2017
ER  -

download .riscopy to clipboard