J Appl Biomed 16:241-246, 2018 | DOI: 10.1016/j.jab.2018.01.004

Effect of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger

Ivan Kushkevycha,*, Monika Vítězováa, Jiří Kosb, Peter Kollárc, Josef Jampílekb,*
a Masaryk University, Faculty of Science, Department of Experimental Biology, Brno, Czech Republic
b Comenius University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Bratislava, Slovak Republic
c University of Veterinary and Pharmaceutical Sciences, Faculty of Pharmacy, Department of Human Pharmacology and Toxicology, Brno, Czech Republic

An increased number of sulfate-reducing bacteria is often isolated from faeces of patients with gastrointestinal diseases, which can be the cause of the development of bowel inflammation. Frequent use of antibiotics causes the resistance of intestinal microorganisms and ineffective treatment of these diseases. The antimicrobial activity and biological properties of the selected ring-substituted 8-hydroxyquinoline-2-carboxanilides against Desulfovibrio piger Vib-7 were studied. The addition of these compounds in the cultivation medium inhibited the bacterial growth and the process of sulfate reduction dose-dependently. A significant cytotoxic activity under the influence of ring-substituted 8-hydroxyquinoline-2-carboxanilides was determined. The strongest cytotoxic effect of the derivatives was observed for compounds 8-hydroxy-N-(3-methoxyphenyl)quinoline-2-carboxamide and 8-hydroxy-N-(3-trifluoromethylphenyl)quinoline-2-carboxamide that caused a low survival of D. piger Vib-7 in concentration 17 μM and high toxicity rates.

Keywords: Sulfate-reducing bacteria; Dissimilatory sulfate reduction; Inflammatory bowel disease; 8-hydroxyquinolines; Structure-activity relationships

Received: August 3, 2017; Revised: January 5, 2018; Accepted: January 15, 2018; Published: August 1, 2018  Show citation

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Kushkevych I, Vítězová M, Kos J, Kollár P, Jampílek J. Effect of selected 8-hydroxyquinoline-2-carboxanilides on viability and sulfate metabolism of Desulfovibrio piger. J Appl Biomed. 2018;16(3):241-246. doi: 10.1016/j.jab.2018.01.004.
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