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The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia

Published online by Cambridge University Press:  11 April 2005

RAYMOND C.K. CHAN ,
RONALD Y.L. CHEN ,
ERIC Y.H. CHEN ,
TOMY C.K. HUI ,
ERIC F.C. CHEUNG ,
H.K. CHEUNG ,
PAK SHAM ,
TAO LI  and
DAVID COLLIER
RAYMOND C.K. CHAN
Affiliation:
Neuropsychology and Applied Cognitive Neuroscience Laboratory, Department of Psychology, Sun Yat-Sen University, Guangzhou, China Department of Psychiatry, the University of Hong Kong, Hong Kong
RONALD Y.L. CHEN
Affiliation:
Department of Psychiatry, the University of Hong Kong, Hong Kong
ERIC Y.H. CHEN
Affiliation:
Department of Psychiatry, the University of Hong Kong, Hong Kong
TOMY C.K. HUI
Affiliation:
Department of Psychiatry, the University of Hong Kong, Hong Kong
ERIC F.C. CHEUNG
Affiliation:
Castle Peak Hospital, Hong Kong
H.K. CHEUNG
Affiliation:
Castle Peak Hospital, Hong Kong
PAK SHAM
Affiliation:
Department of Psychiatry, the University of Hong Kong, Hong Kong Department of Psychiatry, Institute of Psychiatry, London, UK
TAO LI
Affiliation:
Department of Psychiatry, Institute of Psychiatry, London, UK
DAVID COLLIER
Affiliation:
Department of Psychiatry, Institute of Psychiatry, London, UK
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Extract

Schizophrenia is characterized by profound disturbances in cognition, emotion, and social functioning. Catechol-O-methyl transferase (COMT) is the important enzyme for the metabolism of monoamines, which play important part in the pathogenesis of schizophrenia. COMT exists in high and low activity forms. The low activity form was found to be an amino acid substitution (Val-108-Met), which reduces the thermostability of the enzyme. This genetic polymorphism has been reported to be associated with schizophrenia and its associated clinical features (Li et al., 1996).

Type
RAPID COMMUNICATION
Information
Journal of the International Neuropsychological Society , Volume 11 , Issue 2 , March 2005 , pp. 202 - 204
Copyright
© 2005 The International Neuropsychological Society

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