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Übersichtsarbeit

Depressive Störungen im Kindes- und Jugendalter - Eine Übersicht

Published Online:https://doi.org/10.1024/1422-4917.35.6.385

Zusammenfassung: Depressive Störungen im Kindes- und Jugendalter sind ein ernstzunehmendes Gesundheitsrisiko, das eine große Anzahl von Komplikationen und Spätfolgen haben kann. Eine Literaturrecherche in PubMed, Psycontent und Psyndex gibt die gegenwärtige Datenlage wieder und die Ergebnisse werden kritisch diskutiert. Auffällig war die geringe Anzahl an Studien für Kinder und die wenige Beachtung möglicher geschlechterbezogener Unterschiede. Nicht nur im Bezug auf die Epidemiologie, Erkrankungsdauer, Symptomatik, Komorbidität, Entwicklungspsychopathologie werden weitere Untersuchungen notwendig sein, sondern gerade bezüglich einer adäquaten Pharmako- und Psychotherapie sind unumgänglich, um auf die Prognose, Progredienz und Persistenz der Erkrankung erfolgreich Einfluß nehmen zu können.


Depressive disorders in childhood and adolescence

Summary: Childhood depressive disorders are a health risk that need to be taken seriously due to their potential associated complications. A literature search of previously published studies about this subject utilizing PubMed, Psycontent and Psyndex has been performed. The data has been analyzed and the results discussed critically. It becomes apparent that few studies focus on depressive disorders in children and not much consideration is given to possible gender-related differences. Further investigation is needed in regard to epidemiology, symptoms, comorbid factors and duration of these disorders including studying the children’s developmental psychopathology. It is especially essential to establish adequate pharmaco- and psychotherapeutic treatments to ameliorate prognosis, progression and persistence of depressive disorders in children.

Literatur

  • Afifi, T. O. , Enns, M. W. , Cox, B. J. , Martens, P. J. (2005). Investigating health correlates of adolescent depression in Canada. Canadian Journal of Public Health, 96, 427– 431 First citation in articleCrossref MedlineGoogle Scholar

  • Angold, A. , Costello, E. J. , Worthmann, C. M. (1998). Puberty and depression: the roles of age, pubertal status and pubertal timing. Psychological Medicine, 28, 51– 61 First citation in articleCrossref MedlineGoogle Scholar

  • Angold, A. , Costello, E. J. , Erkanli, A. (1999). Comorbidity. Journal of Child Psychologyl Psychiatry, 40, 57– 87 First citation in articleCrossref MedlineGoogle Scholar

  • Angold, A. , Costello, E.J. (2000). The Child and Adolescent Psychiatric Assessment (CAPA). Journal of the American Academy of Child and Adolesent Psychiatry, 39, 39– 48 First citation in articleCrossref MedlineGoogle Scholar

  • Apter, A. , King, R. A. (2006). Management of the depressed, suicidal child or adolescent. Child Adolesc Psychiatric Clinics of North America,, 15, 4 999– 1013 First citation in articleCrossrefGoogle Scholar

  • Arias, E. , MacDorman, M. F. , Strobino, D. M. , Guyer, B. (2003). Annual summary of vital statistics-2002. Pediatrics, 112, 1215– 1230 First citation in articleCrossref MedlineGoogle Scholar

  • Barbe, R. P. , Bridge, J. , Birmaher, B. , Kolko, D. , Brent, D. A. (2004). Suicidality and its relationship to treatment outcome in depressed adolescents. Suicide Life Threatening Behaviour, 34, 44– 55 First citation in articleCrossref MedlineGoogle Scholar

  • Barbe, R. P. , Williamson, D. E. , Bridge, J. A. , Birmaher, B. , Dahl, R. E. , Axelson, D. A. , Ryan, N. D. (2005). Clinical differences between suicidal and nonsuicidal depressed children and adolescents. Journal of Clinical Psychiatry, 66, 492– 498 First citation in articleCrossref MedlineGoogle Scholar

  • Birmaher, B. , Dahl, R. E. , Ryan, N. D. , Rabinovich, H. , Ambrosini, P. , al-Shabbout, M. , Novacenko, H. , Nelson, B. , Puig-Antich, J. (1992). The dexamethasone suppression test in adolescent outpatients with major depressive disorder. American Journal of Psychiatry, 149, 1040– 1045 First citation in articleCrossref MedlineGoogle Scholar

  • Birmaher, B. , Kaufman, J. , Brent, D. A. , Dahl, R. E. , Perel, J. M. , al-Shabbout, M. , Nelson, B. , Stull, S. , Rao, U. , Waterman, G. S. , Williamson, D. E. , Ryan, N. D. (1997). Neuro-endocrine response to 5-hydroxy-L-tryptophan in prepubertal children at high risk of major depressive disorder. Archives of General Psychiatry, 54, 1113– 1119 First citation in articleCrossref MedlineGoogle Scholar

  • Birmaher, B. , Arbelaez, C. , Brent, D. (2002). Course and outcome of child and adolescent major depressive disorder. Child and Adolescent Psychiatric Clinics of North America, 11, 619– 637 First citation in articleCrossref MedlineGoogle Scholar

  • Birmaher, B. , Williamson, D. E. , Dahl, R. E. , Axelson, D. A. , Kaufman, J. , Dorn, L. D. , Ryan, N. D. (2004). Clinical presentation and course of depression in youth: does onset in childhood differ from onset in adolescence?. Journal of the American Academy of Child & Adolecent Psychiatry, 43, 63– 70 First citation in articleCrossref MedlineGoogle Scholar

  • Blazer, D. G. , Kessler, R. C. , McGonagle, K. A. , Swartz, M. S. (1994). The prevalence and distribution of major depression in a national community sample:the National Comorbidity Survey. American Journal of Psychiatry, 151, 979– 986 First citation in articleCrossref MedlineGoogle Scholar

  • Bostic, J. Q. , Rubin, D. H. , Prince, J. , Schlozman, S. (2005). Treatment of depression in children and adolescents. Journal of Psychiatric Practice, 11, 141– 154 First citation in articleCrossref MedlineGoogle Scholar

  • Brent, D. A. , Holder, D. , Kolko, D. , Birmaher, B. , Baugher, M. , Roth, C. , Iyengar, S. , Johnson, B. A. (1997). A clinical psychotherapy trial for adolescent depression comparing cognitive, family, and supportive therapy. Archives of General Psychiatry, 54, 877– 885 First citation in articleCrossref MedlineGoogle Scholar

  • Brent, D. A. , Oquendo, M. , Birmaher, B. , Greenhill, L. , Kolko, D. , Stanley, B. , Zelazny, J. , Brodsky, B. , Bridge, J. , Ellis, S. , Salazar, J. O. , Mann, J. J. (2002). Familial pathways to early-onset suicide attempt: risk for suicidal behavior in offspring of mood-disordered suicide attempters. Archives of General Psychiatry, 59, 801– 807 First citation in articleCrossref MedlineGoogle Scholar

  • Bridge, J. A. , Barbe, R. P. , Birmaher, B. , Kolko, D. J. , Brent, D.A. (2005). Emergent suicidality in a clinical psychotherapy trial for adolescent depression. American Journal of Psychiatry, 162, 2173– 2175 First citation in articleCrossref MedlineGoogle Scholar

  • Bridge, J. A. , Iyengar, S. , Salary, C. B. , Barbe, R. P. , Birmaher, B. , Pincus, H. A. , Ren, L. , Brent, D. A. (2007). Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment. Journal of the American Medical Association, 297, 1683– 1696 First citation in articleCrossrefGoogle Scholar

  • Cadoret, R. J. (1978). Evidence for genetic inheritance of primary affective disorder in adoptees. American Journal of Psychiatry, 135, 463– 466 First citation in articleCrossref MedlineGoogle Scholar

  • Carlson, G. A. , Kashani, J. H. (1988). Phenomenology of major depression from childhood through adulthood: analysis of three studies. American Journal of Psychiatry, 145, 1222– 1225 First citation in articleCrossref MedlineGoogle Scholar

  • Caspi, A. , Sudgen, K. , Moffitt, T. E. et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science, 301, 386– 389 First citation in articleCrossref MedlineGoogle Scholar

  • Cicchetti, D. , Toth, S. L. (1998). The development of depression in children and adolescents. American Psychologist, 53, 221– 241 First citation in articleCrossref MedlineGoogle Scholar

  • Cooper, P. J. , Goodyer, I. (1993). A community study of depression in adolescent girls. II: The clinical features of identified disorder. British Journal of Psychiatry, 163, 374– 380 First citation in articleCrossref MedlineGoogle Scholar

  • Coppen, A. (1967). The biochemistry of affective disorders. British Journal of Psychiatry, 113, 1237– 1264 First citation in articleCrossref MedlineGoogle Scholar

  • Costello, E. J. , Angold, A. (1988). Scales to assess child and adolescent depression: checklists, screens, and nets. Journal of the American Academy of Child & Adolecent Psychiatry, 27, 726– 737 First citation in articleCrossref MedlineGoogle Scholar

  • Costello, E. J. , Pine, D. S. , Hammen, C. , March, J. S. , Plotsky, P. M. , Weissmann, M. M. , Biederman, J. , Goldsmith, H. H. , Kaufman, J. , Lewinsohn, P. M. , Hellander, M. , Hoagwood, K. , Koretz, D. S. , Nelson, C. A. , Leckman, J. F. (2002). Development and natural history of mood disorders. Biological Psychiatry, 52, 529– 542 First citation in articleCrossref MedlineGoogle Scholar

  • Costello, E. J. , Egger, H. , Angold, A. (2005). 10-year research update review: the epidemiology of child and adolescent psychiatric disorders: I. Methods and public health burden. Journal of the American Academy of Child & Adolecent Psychiatry, 44, 972– 986 First citation in articleCrossref MedlineGoogle Scholar

  • Costello, E. J. , Foley, D. L. , Angold, A. (2006). 0-year research update review: the epidemiology of child and adolescent psychiatric disorders: II. Develop-mental epidemiology. Journal of the American Academy of Child & Adolecent Psychiatry, 45, 8– 25 First citation in articleCrossref MedlineGoogle Scholar

  • Dahl, R. E. , Kaufman, J. , Ryan, N. D. , Perel, J. , al-Shabbout, M. , Birmaher, B. , Nelson, B. , Puig-Antich, J. (1992). The dexamethasone suppression test in children and adolescents: a review and a controlled study. Biol Psychiatry, 32, 109– 126 First citation in articleCrossref MedlineGoogle Scholar

  • Dahl, R. E. , Birmaher, B. , Williamson, D. E. , Dorn, L. , Perel, J. , Kaufman, J. , Brent, D. A. , Axelson, D. A. , Ryan, N. D. (2000). Low growth hormone response to growth hormone-releasing hormone in child depression. Biological Psychiatry, 48, 981– 988 First citation in articleCrossref MedlineGoogle Scholar

  • Deutsche Gesellschaft für Kinder- und Jugendpsychiatrie, Psychoomatik und Psychotherapie e.V., (2004). www.dgkjp. de First citation in articleGoogle Scholar

  • Emslie, G. , Kratochvil, C. , Vitiello, B. , Silva, S. , Mayes, T. , McNulty, S. , Weller, E. , Waslick, B. , Casat, C. , Walkup, J. , Pathak, S. , Rohde, P. , Posner, K. , March, J. , Columbia Suicidality Classification Group, TADS Team (2006). Treatment for Adolescents with Depression Study (TADS): safety results. Journal of the American Academy of child and adolescent Psychiatry, 45, 1440– 1455 First citation in articleCrossref MedlineGoogle Scholar

  • Fegert, J. M. , Herpertz-Dahlmann, B. (2004). Zum Einsatz von selektiven Serotonin-wiederaufnahmehemmern(SSRI) bei Kindern und Jugendlichen. www.dgkjp.de First citation in articleGoogle Scholar

  • Flament, M. F. , Cohen, D. , Choquet, M. , Jeammet, P. , Ledoux, S. (2001). Phenomen-ology, psychosocial correlates, and treatment seeking in major depression and dysthymia of adolescence. Journal of the American Academy of Child & Adolecent Psychiatry, 40, 1070– 1078 First citation in articleCrossref MedlineGoogle Scholar

  • Fombonne, E. , Wostear, G. , Cooper, V. , Harrington, R. , Rutter, M. (2001). The Maudsley long-term follow-up of child and adolescent depression. 2. Suicidality, crim-inality and social dysfunction in adulthood. British Journal of Psychiatry, 179, 218– 223 First citation in articleCrossref MedlineGoogle Scholar

  • Gadow, K. D. , Sprafkin, J. M. , Nolan, E. (2001). DSM-IV symptoms in community and clinical preschool children. Journal of the American Academy of Child & Adolecent Psychiatry, 40, 1383– 1392 First citation in articleCrossref MedlineGoogle Scholar

  • Garber, J. (2006). Depression in children and adolescents. Linking risk research and prevention. American Journal of Preventive Medicine, 31, 104– 125 First citation in articleCrossrefGoogle Scholar

  • Groen, G. , Petermann, F. (2005). Depressive Störungen im Jugendalter: Verlauf und klinische Prädiktoren. Zeitschrift für Klinische Psychologie und Psychotherapie, 34, 10– 18 First citation in articleLinkGoogle Scholar

  • Harrington, R. C. , Fudge, H. , Rutter, M. , Pickles, A. , Hill, J. (1990). Adult outcomes of childhood and adolescent depression. I. Psychiatric status. Archives of General Psychiatry, 47, 465– 473 First citation in articleCrossref MedlineGoogle Scholar

  • Harrington, R. , Whittaker, J. , Shoebridge, P. , Campbell, F. (1998). Systematic review of efficacy of cognitive behaviour therapies in childhood and adolescent depressive disorder. British Medical Journal, 31, 1559– 1563 First citation in articleCrossrefGoogle Scholar

  • Harrington, R. C. (2001). Kognitive Verhaltenstherapie bei depressiven Kindern und Jugendlichen. Hogrefe-Verlag, Reihe: Therapeutische Praxis, 12, First citation in articleGoogle Scholar

  • Haug, H. J. (1996). Affektive Störungen. In: H. J. Freyberger, R. D. Stieglitz. (Hrsg.), Kompendium der Psychiatrie und Psychotherapie. Basel: Karger First citation in articleGoogle Scholar

  • Hautzinger, M. , Petermann, F. (2003). Depression im Kindes- und Jugendalter- Einführung in den Themenschwerpunkt. Kindheit und Entwicklung, 12, 127– 132 First citation in articleLinkGoogle Scholar

  • Heiser, P. , Remschmidt, H. (2002). Die selektiven Serotonin-Wiederaufnahmehemmer und die neueren Antidepressivasubstanzen in der Kinder- und Jugendpsychiatrie. Zeitschrift für Kinder und Jugendpsychiatrie und -psychotherapie, 3, 173– 183 First citation in articleLinkGoogle Scholar

  • Hünnerkopf, R. , Lesch, K. P. (2006). Die Genetik der Depression. Medizinische Genetik, 2, 160– 165 First citation in articleGoogle Scholar

  • Hulten, A. , Jiang, G. X. , Wasserman, D. , Hawton, K. , Hjelmeland, H. , De Leo, D. , Ostamo, A. , Salander-Renberg, E. , Schmidtke, A. (2001). Repetition of attempted suicide among teenagers in Europe: frequency, timing and risk factors. European Child and Adolescent Psychiatry, 10, 161– 169 First citation in articleGoogle Scholar

  • Ihle, W. , Esser, G. , Schmidt, M. , Blanz, B. (2000). Prävalenz, Komorbidität und Geschlechterunterschiede psychischer Störungen vom Grundschul- bis ins frühe Erwachsenen-alter. Zeitschrift für Klinische Psychologie und Psychotherapie, 29, 263– 275 First citation in articleLinkGoogle Scholar

  • Ihle, W. , Herrle, J. (2003). Stimmungsprobleme bewältigen, 2 Bde. Dgvt-Verlag, First citation in articleGoogle Scholar

  • Ihle, W. , Jahnke, D. , Ahle, M. E. (2006). Depressive Störungen. In: F. Mattejat (Hrsg.), Lehrbuch der Psychotherapie für die Ausbildung zum Kinder- und Jugendlichenpsychotherapeuten und für die ärztliche Weiterbildung. Band 4, CIP-Medien Verlag First citation in articleGoogle Scholar

  • Kashani, J. H. , McGee, R. O. , Clarkson, S. E. , Anderson, J. C. , Silva, P. A. , Robins, A. J. , Cytryn, L. , McKnew, D. H. (1983). Depression in a sample of 9-year-old children, Prevalence and associated characteristics. Archives of General Psychiatry, 40, 1217– 1223 First citation in articleCrossref MedlineGoogle Scholar

  • Kashani, J. H. , Carlson, G. A. , Beck, N. C. , Hoeper, E. W. , Corcoran, C. M. , McAllister, J. A. , Fallahi, C. , Rosenberg, T. K. , Reid, J. C. (1987). Depression, depressive symptoms, and depressed mood among a community sample of adolescents. American Journal of Psychiatry, 144, 931– 934 First citation in articleCrossref MedlineGoogle Scholar

  • Kashani, J. H. , Carlson, G. A. (1987). Seriously depressed preschoolers. American Journal of Psychiatry, 144, 348– 350 First citation in articleCrossref MedlineGoogle Scholar

  • Kashani, J. H. , Sherman, D. D. (1988). Childhood depression. Epidemiology, etiological models, and treatment implications. Integrative Psychiatry, 6, 1– 8 First citation in articleGoogle Scholar

  • Keenan, K. , Hipwell, A. , Duax, J. , Stouthamer-Loeber, M. , Loeber, R. (2004). Pheno-menology of depression in young girls. . Journal of the American Academy of Child & Adolecent Psychiatry, 43, 9 1098– 1102 First citation in articleGoogle Scholar

  • Kessler, R. C. , Berglund, P. , Demler, O. , Jin, R. , Koretz, D. , Merikangas, K. R. , Rush, A. J. , Walters, E. E. , Wang, P. S. (2003). The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). Journal of the American Academy Association, 289, 3095– 3105 First citation in articleCrossref MedlineGoogle Scholar

  • Klein, D. N. , Lewinsohn, P. M. , Rohde, P. , Seeley, J. R. , Olino, T. M. (2005). Psychopathology in the adolescent and young adult offspring of a community sample of mothers and fathers with major depression. Psychological Medicine, 35, 353– 365 First citation in articleCrossref MedlineGoogle Scholar

  • Kovacs, M. (1996). Presentation and course of major depressive disorder during childhood and later years of the life span. Journal of the American Academy of Child & Adolecent Psychiatry, 35, 705– 715 First citation in articleCrossref MedlineGoogle Scholar

  • Kovacs, M. , Obrosky, D. S. , Sherrill, J. (2003). Developmental changes in the phenomenology of depression in girls compared to boys from childhood onward. Journal of Affective Disorders, 74, 33– 48 First citation in articleCrossref MedlineGoogle Scholar

  • Lewinsohn, P. M. , Roberts, R. E. , Seeley, J. R. , Rohde, P. , Gotlib, I. H. , Hops, H. (1994). Adolescent psychopathology: II. Psychosocial risk factors for depression. Journal of Abnormal Psychology, 103, 302– 315 First citation in articleCrossref MedlineGoogle Scholar

  • Lewinsohn, P. M. , Gotlib, I. H. , Seeley, J. R. (1995). Adolescent psychopathology: IV. Specificity of psychosocial risk factors for depression and substance abuse in older adolescents. Journal of the American Academy of Child & Adolecent Psychiatry, 34, 1221– 1229 First citation in articleCrossref MedlineGoogle Scholar

  • Lewinsohn, P. M. , Rohde, P. , Seeley, J. R. (1998). major depressive disorder in older adolescents: prevalence, risk factors, and clinical implications. Clinical Psychological Review, 18, 765– 794 First citation in articleCrossref MedlineGoogle Scholar

  • Lewinsohn, P. M. (1999). Natural course of adolescent major depressive disorder: I. Continuityinto young adulthood. Journal of the American Academy of Child & Adolecent Psychiatry, 38, 56– 63 First citation in articleCrossref MedlineGoogle Scholar

  • Lewinsohn, P. M. , Rohde, P. , Seeley, J. R. , Baldwin, C. L. (2001). Gender differences in suicide attempts from adolescence to young adulthood. Journal of the American Academy of Child & Adolecent Psychiatry, 40, 427– 434 First citation in articleCrossref MedlineGoogle Scholar

  • Luby, J. L. , Heffelfinger, A. K. , Mrakotsky, C. , Hessler, M. J. , Brown, K. M. , Hildebrand, T. (2002). Preschool major depressive disorder: preliminary validation for developmentally modified DSM-IV criteria. Journal of the American Academy of Child & Adolecent Psychiatry, 41, 928– 937 First citation in articleCrossref MedlineGoogle Scholar

  • March, J. , Silva, S. , Petrycki, S. , Curry, J. , Wells, K. , Fairbank, J. , Burns, B. , Domino, M. , McNulty, S. , Vitiello, B. , Severe, J. (2004). Treatment for Adolescents With Depression Study (TADS) Team. Journal of the American Medical Association, 292, 807– 820 First citation in articleCrossref MedlineGoogle Scholar

  • Michael, K. D. , Crowley, S. L. (2002). How effective are treatments for child and adol-escent depression? A meta-analytic review. Clinical Psychology Review, 22, 247– 269 First citation in articleCrossref MedlineGoogle Scholar

  • Mufson, L. , Dorta, K. P. , Wickramaratne, P. , Nomura, Y. , Olfson, M. , Weissman, M. M. (2004). A randomized effectiveness trial of interpersonal psychotherapy for depressed adolescents. Archives of General Psychiatry, 61, 577– 584 First citation in articleCrossref MedlineGoogle Scholar

  • Pössel, P. , Horn, A. B. , Seemann, S. , Hautzinger, M. (2004). Trainingsprogramm zur Prävention von Depressionen bei Jugendlichen. LARS & LISA. Hogrefe-Verlag, Reihe: Therapeutische Praxis, 23, First citation in articleGoogle Scholar

  • Pössel, P. , Hautzinger, M. (2006). Effekte pharmakologischer und psychotherapeutischer Interventionen auf Depressionen bei Kindern und Jugendlichen. Zeitschrift für Kinder- und Jugendpsychiatrie und -psychotherapie, 34, 243– 255 First citation in articleLinkGoogle Scholar

  • Reinecke, M. A. , Ryan, N. E. , DuBois, D. L. (1998). Cognitive-behavioral therapy of depression and depressive symptoms during adolescence: a review and meta-analysis. Journal of the American Academy of Child & Adolecent Psychiatry, 37, 26– 34 First citation in articleCrossref MedlineGoogle Scholar

  • Reinherz, H. Z. , Giaconia, R. M. , Pakiz, B. , Frost, A. K. , Lefkowitz, E. S. (1993). Psychosocial risks for major depression in late adolescence: a longitudinal community study. Journal of the American Academy of Child & Adolecent Psychiatry, 32, 1155– 1163 First citation in articleCrossref MedlineGoogle Scholar

  • Remschmidt, H. (2005). Kinder- und Jugendpsychiatrie- eine praktische Einführung. Thieme-Verlag, 4. Auflage First citation in articleGoogle Scholar

  • Roberts, R. E. , Lewinsohn, P. M. , Seeley, J. R. (1995a). Symptoms of DSM-III-R major depression in adolescence: evidence from an epidemiological survey. Journal of the American Academy of Child & Adolecent Psychiatry, 34, 1608– 1617 First citation in articleCrossref MedlineGoogle Scholar

  • Rohde, P. , Lewinsohn, P. M. , Seeley, J. R. (1994). Are adolescents changed by an episode of major depression?. Journal of the American Academy of Child & Adolecent Psychiatry, 3, 1289– 1298 First citation in articleCrossrefGoogle Scholar

  • Rutter, M. (1991). Age changes in depressive disorders: some developmental considerations. In: J. Garber, K. A. Dodge . (eds), The development of Emotion. Regulation and Dysregulation. Cambridge University Press, 273-300 First citation in articleGoogle Scholar

  • Ryan, N. D. , Birmaher, B. , Perel, J. M. , Dahl, R. E. , Meyer, V. , al-Shabbout, M. , Iyengar, S. , Puig-Antich, J. (1992). Neuroendocrine response to L-5-hydroxytryptophan challenge in prepubertal major depression. Depressed vs normal children. Archives of General Psychiatry, 49, 843– 851 First citation in articleCrossref MedlineGoogle Scholar

  • Ryan, N. D. , Dahl, R. E. , Birmaher, B. , Williamson, D. E. , Iyengar, S. , Nelson, B. , Puig-Antich, J. , Perel, J. M. (1994). Stimulatory tests of growth hormone secretion in prepubertal major depression: depressed versus normal children. Journal of the American Academy of Child & Adolecent Psychiatry, 33, 824– 833 First citation in articleCrossref MedlineGoogle Scholar

  • Ryan, N. D. , Varma, D. (1998). Child and adolescent mood disorders-experience with serotonin-based therapies. Biological Psychiatry, 44, 336– 340 First citation in articleCrossref MedlineGoogle Scholar

  • Ryan, N. D. (2005). Treatment of depression in children and adolescents. Lancet, 366, 9489 933– 940 First citation in articleCrossrefGoogle Scholar

  • Schmidt, P. , Muller, R. , Dettmeyer, R. , Madea, B. (2002). Suicide in children, adolescents and young adult. Forensic Science International, 127, 161– 167 First citation in articleCrossref MedlineGoogle Scholar

  • Shaw, D. , Fernandes, J. R. , Rao, C. (2005). Suicide in children and adolescents: a 10-year retrospective review. American Journal of Forensic Medicine and Pathology, 26, 309– 315 First citation in articleCrossref MedlineGoogle Scholar

  • Shih, R. A. , Belmonte, P. L. , Zandi, P. P. (2004). A review of the evidence from familiy, twin and adoption studies for a genetic contribution to adult psychiatric disorders. International Review of Psychiatry, 16, 260– 283 First citation in articleCrossref MedlineGoogle Scholar

  • Simeon, J. , Nixon, M. K. , Milin, R. , Jovanovic, R. , Walker, S. (2005). Open-label pilot study of St. John’s wort in adolescent depression. Journal of Child & Adolescent Psychopharmacology, 15, 293– 301 First citation in articleCrossref MedlineGoogle Scholar

  • Steingard, R. J. , Renshaw, P. F. , Yurgelun-Todd, D. , Appelmans, K. E. T. Y. , Barnes, P. (1996). Structural abnormalities in brain magnetic resonance images of depressed children. Journal of the American Academy of Child & Adolecent Psychiatry, 35, 307– 311 First citation in articleCrossref MedlineGoogle Scholar

  • Target, M. , Fonagy, P. (1994). The efficacy of psychoanalysis for children: prediction of outcome in a developmental context. Journal of the American Academy of Child & Adolecent Psychiatry, 33, 1134– 1144 First citation in articleCrossref MedlineGoogle Scholar

  • Warner, V. , Weissman, M. M. , Mufson, L. , Wickramaratne, P. (1999). Grandparents, parents and grandchildren at high risk for depression: a three-generation study. American Academy of Child and Adolescent Psychiatry, 38, 289– 296 First citation in articleCrossref MedlineGoogle Scholar

  • Weissman, M. M. , Wickramaratne, P. , Moreau, D. , Olfson, M. (1997). Offspring of depressed parents. 10 Years later. Archives of General Psychiatry, 54, 932– 940 First citation in articleCrossref MedlineGoogle Scholar

  • Weissman, M. M. , Wickramaratne, P. , Nomura, Y. , Warner, V. , Verdeli, H. , Pilowsky, D. J. , Grillon, C. , Bruder, G. (2005). Families at high and low risk for depression: a 3-generation study. Archives of General Psychiatry, 62, 29– 36 First citation in articleCrossref MedlineGoogle Scholar

  • Weisz, J. R. , McCarty, C. A. , Valeri, S. M. (2006). Effects of psychotherapy for depression in children and adolescents: a meta-analysis. Psychological Bulletin, 132, 132– 149 First citation in articleCrossref MedlineGoogle Scholar

  • Williamson, D. E. , Birmaher, B. , Axelson, D. A. , Ryan, N. D. , Dahl, R. E. (2004). First episode of depression in children at low and high familial risk for depression. Journal of the American Academy of Child & Adolecent Psychiatry, 43, 291– 297 First citation in articleCrossref MedlineGoogle Scholar

  • Wittchen, H. U. , Nelson, C. B. , Lachner, G. (1998). Prevalence of mental disorders and psychosocial impairments in adolescents and young adults. Psychological Medicine, Jan 28, 109– 126 First citation in articleCrossref MedlineGoogle Scholar

  • World Health Organization, (1996). The Global Burden of Disease. Geneva, Switzerland. World Health Organization Press First citation in articleGoogle Scholar