Skip to main content
Search
Search
    Quick Search anywhere
    Quick search in Citations
Advanced Search
Skip main navigationClose Drawer MenuOpen Drawer Menu
Previous article
Next article
Grundlagen

Aufmerksamkeitsstörungen im Kindesalter

Erkenntnisse funktioneller Magnetresonanztomographie

Published Online:February 05, 2007https://doi.org/10.1026/0942-5403.16.1.7

Abstract

Zusammenfassung. Der vorliegende Übersichtsartikel beschäftigt sich mit der Bedeutung der funktionellen Kernspintomographie (fMRT) für diagnostische und therapeutische Aspekte von kindlichen Aufmerksamkeitsstörungen. Nach einer kurzen Einführung in die Methode und ihre Besonderheiten bei der Anwendung im Kindesalter, werden Ergebnisse aus fMRT-Studien bei Kindern mit einem Aufmerksamkeitsdefizit/Hyperaktivitätssyndrom (ADHS) zusammengefasst. Abschließend werden weitergehende Chancen und Nutzen der funktionellen Kernspintomographie für die klinische Praxis und zukünftige Forschungsperspektiven diskutiert.


Attentional dysfunction in childhood. Findings from functional neuroimaging

Abstract. This review gives an overview of functional magnet resonance imaging in children with attentional dysfunction and its clinical implications. After a short introduction of the method and a description of children's specific requirements, findings from functional imaging studies in children with attention deficit/hyperactivity disorder (ADHD) are summarized. Finally, future clinical and research perspectives are discussed.

Literatur

  • Anderson, C. M. , Polcari, A. , Lowen, S. B. , Renshaw, P. F. , Teicher, M. H. (2002). Effects of methylphenidate on functional magnetic resonance relaxometry of the cerebellar vermis in boys with ADHD. American Journal of Psychiatry , 159 , 1322– 1328 . First citation in articleCrossref, Google Scholar

  • Booth, J. R. , Burman, D. D. , Meyer, J. R. , Lei, Z. , Trommer, B. L. , Davenport, N. D. , Li, W. , Parrish, T. B. , Gitelman, D. R. , Mesulam, M. M. (2005). Larger deficits in brain networks for response inhibition than for visual selective attention in attention deficit hyperactivity disorder (ADHD). Journal of Child Psychology and Psychiatry , 46 , 94– 111 . First citation in articleCrossref, Google Scholar

  • Collicutt, J. H. , Weinberger, D. R. (2003). Brain imaging as an approach to phenotype characterization for genetic studies of schizophrenia. Methods in Molecular Medicine , 77 , 227– 247 . First citation in articleGoogle Scholar

  • Chugani, H. T. (2006). What can we learn from functional neuroimaging in children?. Indian Pediatrics , 43 , 203– 206 . First citation in articleGoogle Scholar

  • Davidson, M. C. , Thomas, K. M. , Casey, B. J. (2003). Imaging the developing brain with fMRI. Mental Retardation and Developmental Disabilities , 9 , 161– 167 . First citation in articleCrossref, Google Scholar

  • Desman, C. , Petermann, F. (2005). Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS): Wie valide sind die Subtypen?. Kindheit und Entwicklung , 14 , 244– 254 . First citation in articleLink, Google Scholar

  • Durston, S. , Tottenham, N. T. , Thomas, K. M. , Davidson, M. C. , Eigsti, I. M. , Yang, Y. , Ulug, A. M. , Casey, B. J. (2003). Differential patterns of striatal activation in young children with and without ADHD. Biological Psychiatry , 53 , 871– 878 . First citation in articleCrossref, Google Scholar

  • Durston, S. , Mulder, M. , Casey, B. J. , Ziermans, T. , van Engeland, H. (2006). Activation in ventral prefrontal cortex is sensitive to genetic vulnerability for attention-deficit hyperactivity disorder. Biological Psychiatry , 60 , 1062– 1070 . First citation in articleCrossref, Google Scholar

  • Ernst, M. , Rumsey, J. M. (2000). Functional neuroimaging in child psychiatry. Cambridge: Cambridge University Press . First citation in articleCrossref, Google Scholar

  • Fan, J. , Fossella, J. , Sommer, T. , Wu, Y. , Posner, M. I. (2003). Mapping the genetic variation of executive attention onto brain activity. Proceedings of the National Academy of Sciences USA , 100 , 7406– 7411 . First citation in articleGoogle Scholar

  • Fink, G. R. , Marshall, J. C. , Weiss, P. H. , Toni, I. , Zilles, K. (2002). Task instructions influence the cognitive strategies involved in line bisection judgements: evidence from modulated neural mechanisms revealed by fMRI. Neuropsychologia , 40 , 119– 130 . First citation in articleCrossref, Google Scholar

  • Hanisch, C. , Konrad, K. , Günther, T. , Herpertz-Dahlmann, B. (2004). Age-dependent neuropsychological deficits and effects of Methylphenidate in children with attention-deficit/hyperactivity disorder: a comparison of pre- and grade-school children. Journal of Neural Transmission , 111 , 865– 881 . First citation in articleCrossref, Google Scholar

  • Hartman, C. A. , Hox, J. , Mellenbergh, G. J. , Boyle, M. H. , Offord, D. R. , Racine, Y. , McNamee, J. , Gadow, K. D. , Sprafkin, J. , Kelly, K. L. , Nolan, E. E. , Tannock, R. , Schachar, R. , Schut, H. , Postma, I. , Drost, R. , Sergeant, J. A. (2001). DSM-IV internal construct validity: When a taxonomy meets data. Journal of Child Psychology and Psychiatry , 42 , 817– 836 . First citation in articleCrossref, Google Scholar

  • Heubrock, D. , Petermann, F. (2000). Lehrbuch der Klinischen Kinderneuropsychologie. Göttingen: Hogrefe . First citation in articleGoogle Scholar

  • Heubrock, D. , Petermann, F. (2001). Aufmerksamkeitsdiagnostik. Göttingen: Hogrefe . First citation in articleGoogle Scholar

  • Huang-Pollock, C. L. , Nigg, J. T. (2003). Searching for the attention deficit in attention deficit hyperactivity disorder: The case of visuospatial orienting. Clinical Psychological Review , 23 , 801– 830 . First citation in articleCrossref, Google Scholar

  • Johnson, M. H. (2000). Developing an attentive brain. In R. Parasuraman (Ed.), The attentive brain (pp.427-444). Boston: MIT Press . First citation in articleGoogle Scholar

  • Konrad, K. , Herpertz-Dahlmann, B. (2003). Neuropsychologische Diagnostik bei Kindern und Jugendlichen mit ADHS. Kinder- und Jugendmedizin , 3 , 143– 147 . First citation in articleGoogle Scholar

  • Konrad, K. , Neufang, S. , Hanisch, C. , Fink, G. R. , Herpertz-Dahlmann, B. (2006). Dysfunctional attentional networks in children with attention deficit/hyperactivity disorder: evidence from an event-related functional magnetic resonance imaging study. Biological Psychiatry , 59 , 643– 651 . First citation in articleCrossref, Google Scholar

  • Lévesque, J. , Beauregard, M. , Mensour, B. (2006). Effect of neurofeedback training on the neural substrates of selective attention in children with attention-deficit/hyperactivity disorder: A functional magnetic resonance imaging study. Neuroscience Letter , 20, 394 , 216– 221 . First citation in articleCrossref, Google Scholar

  • Martinussen, R. , Hayden, J. , Hogg-Johnson, S. , Tannock, R. (2005). A meta-analysis of working memory impairments in children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry , 44 , 377– 384 . First citation in articleCrossref, Google Scholar

  • Matochik, J. A. , Liebenauer, L. L. , King, A. C. , Szymanski, H. V. , Cohen, R. M. , Zametkin, A. J. (1994). Cerebral glucose metabolism in adults with attention deficit hyperactivity disorder after chronic stimulant treatment. American Journal of Psychiatry , 151 , 658– 664 . First citation in articleCrossref, Google Scholar

  • Matochik, J. A. , Nordahl, T. E. , Gross, M. , Semple, W. E. , King, A. C. , Cohen, R. M. , Zametkin, A. J. (1993). Effects of acute stimulant medication on cerebral metabolism in adults with hyperactivity. Neuropsychopharmacology , 8 , 377– 386 . First citation in articleCrossref, Google Scholar

  • Max, J. E. , Schachar, R. J. , Levin, H. S. , Ewing-Cobbs, L. , Chapman, S. B. , Dennis, M. , Saunders, A. , Landis, J. (2005). Predictors of secondary attention-deficit/hyperactivity disorder in children and adolescents 6 to 24 months after traumatic brain injury. Journal of the American Academy of Child and Adolescent Psychiatry , 44 , 1041– 1049 . First citation in articleCrossref, Google Scholar

  • Munakata, Y. , Casey, B. J. , Diamond, A. (2004). Developmental cognitive neuroscience: Progress and potential. Trends in Cognitive Sciences , 8 , 122– 128 . First citation in articleCrossref, Google Scholar

  • Nigg, J. T. (2001). Is ADHD a disinhibitory disorder?. Psychological Bulletin , 127 , 571– 598 . First citation in articleCrossref, Google Scholar

  • Nigg, J. T. (2005). Neuropsychologic theory and findings in attention-deficit/hyperactivity disorder: The state of the field and salient challenges for the coming decade. Biological Psychiatry , 57 , 1424– 1435 . First citation in articleCrossref, Google Scholar

  • O'Tuama, L. A. , Dickstein, D. P. , Neeper, R. , Gascon, G. G. (1999). Functional brain imaging in neuropsychiatric disorders of childhood. Journal of Child Neurology , 14 , 207– 221 . First citation in articleGoogle Scholar

  • Pennington, B. F. , Ozonoff, S. (1996). Executive functions and developmental psychopathology. Journal of Child Psychology and Psychiatry , 37 , 51– 87 . First citation in articleCrossref, Google Scholar

  • Petermann, F. (2005). Epidemiologie psychischer Störungen im Kindes- und Jugendalter. Eine Bestandsaufnahme. Kindheit und Entwicklung , 14 , 48– 57 . First citation in articleLink, Google Scholar

  • Pliszka, S. R. , Glahn, D. C. , Semrud-Clikeman, M. , Franklin, C. , Perez, R. 3rd , Xiong, J. , Liotti, M. (2006). Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naive or in long-term treatment. American Journal of Psychiatry , 163 , 1052– 1060 . First citation in articleCrossref, Google Scholar

  • Rubia, K. , Overmeyer, S. , Taylor, E. , Brammer, M. , Williams, S. C. , Simmons, A. , Bullmore, E. T. (1999). Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: A study with functional MRI. American Journal of Psychiatry , 156 , 891– 896 . First citation in articleCrossref, Google Scholar

  • Rubia, K. , Taylor, E. , Smith, A. B. , Oksannen, H. , Overmeyer, S. , Newman, S. (2001). Neuropsychological analyses of impulsiveness in childhood hyperactivity. British Journal of Psychiatry , 179 , 138– 143 . First citation in articleCrossref, Google Scholar

  • Rubia, K. , Smith, A. B. , Brammer, M. J. , Toone, B. , Taylor, E. (2005). Abnormal brain activation during inhibition and error detection in medication-naive adolescents with ADHD. American Journal of Psychiatry , 162 , 1067– 1075 . First citation in articleCrossref, Google Scholar

  • Silk, T. , Vance, A. , Rinehart, N. , Egan, G. , O'Boyle, M. , Bradshaw, J. L. , Cunnington, R. (2005). Fronto-parietal activation in attention-deficit hyperactivity disorder, combined type: functional magnetic resonance imaging study. British Journal of Psychiatry , 187 , 282– 283 . First citation in articleCrossref, Google Scholar

  • Smith, A. B. , Taylor, E. , Brammer, M. , Toone, B. , Rubia, K. (2006). Task-specific hypoactivation in prefrontal and temporoparietal brain regions during motor inhibition and task switching in medication-naive children and adolescents with attention deficit hyperactivity disorder. American Journal of Psychiatry , 163 , 1044– 1051 . First citation in articleCrossref, Google Scholar

  • Schulz, K. P. , Fan, J. , Tang, C. Y. , Newcorn, J. H. , Buchsbaum, M. S. , Cheung, A. M. , Halperin J., M. (2004). Response inhibition in adolescents diagnosed with attention deficit hyperactivity disorder during childhood: an event-related fMRI study. American Journal of Psychiatry , 161 , 1650– 1657 . First citation in articleCrossref, Google Scholar

  • Spear, S. L. (2002). The adolescent brain and age related behavioral manifestations. Neuroscience and Biobehavioral Reviews , 24 , 417– 463 . First citation in articleCrossref, Google Scholar

  • Solanto, M. V. (2002). Dopamine dysfunction in AD/HD: integrating clinical and basic neuroscience research. Behavioral Brain Research , 13 , 65– 71 . First citation in articleCrossref, Google Scholar

  • Sturm, W. (2005). Aufmerksamkeitsstörungen. Göttingen: Hogrefe . First citation in articleCrossref, Google Scholar

  • Teicher, M. H. , Anderson, C. M. , Polcari, A. , Glod, C. A. , Maas, L. C. , Renshaw, P. F. (2000). Functional deficits in basal ganglia of children with attention-deficit/hyperactivity disorder shown with functional magnetic resonance imaging relaxometry. Nature Medicine , 6 , 470– 473 . First citation in articleCrossref, Google Scholar

  • Tian, L. , Jiang, T. , Wang, Y. , Zang, Y. , He, Y. , Liang, M. , Sui, M. , Cao, Q. , Hu, S. , Peng, M. , Zhuo, Y. (2006). Altered resting-state functional connectivity patterns of anterior cingulate Kortex in adolescents with attention deficit hyperactivity disorder. Neuroscience Letter , 29, 400 , 39– 43 . First citation in articleCrossref, Google Scholar

  • Vaidya, C. J. , Austin, G. , Kirkorian, G. (1998). Selective effects of methylphenidate in attention deficit hyperactivity disorder: A functional magnetic resonance study. Proceedings of the National Academy of Sciences USA , 95 , 14494– 14499 . First citation in articleGoogle Scholar

  • Vaidya, C. J. , Bunge, S. A. , Dudukovic, N. M. , Zalecki, C. A. , Elliott, G. R. , Gabrieli, J. D. (2005). Altered neural substrates of cognitive control in childhood ADHD: Evidence from functional magnetic resonance imaging. American Journal of Psychiatry , 162 , 1605– 1613 . First citation in articleCrossref, Google Scholar

  • Volkow, N. D. (2002). Pharmacokinetic and pharmacodynamic properties of stimulants: Implications for the design of new treatments for ADHD. Behavioral Brain Research , 130 , 73– 78 . First citation in articleCrossref, Google Scholar

  • Wirtz, M. , Schleider, K. , Krause, A. (2006). Entwicklung und konfirmatorische Prüfung eines Rasch-skalierten Beurteilungsbogens für die Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung im Grundschulalter. Kindheit und Entwicklung , 15 , 170– 181 . First citation in articleLink, Google Scholar