The nuclear matrix has remained a contentious structure for decades; many believe that it is an artefact of harsh non-physiological procedures. However, its visualization using milder experimental techniques is leading to its general acceptance by the scientific community. It is a permanent network of core filaments underlying thicker fibres which is proposed to be a platform for numerous important nuclear activities such as transcription and DNA repair. Interestingly, A- and B-type lamin proteins and emerin are components of this nuclear structure; however, they are often referred to only as nuclear envelope proteins. The present mini-review intends to provide an overview of the nuclear matrix, mentioning both its constituents and functional significance. The impact of disease-causing mutations in both emerin and lamin proteins on the structure's ability to regulate and mediate nuclear processes is then discussed.
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Conference Article|
November 19 2008
Exploring the effects of a dysfunctional nuclear matrix
Lauren S. Elcock;
Lauren S. Elcock
1Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, Brunel University, Uxbridge UB8 3PH, U.K.
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Joanna M. Bridger
Joanna M. Bridger
1
1Laboratory of Nuclear and Genomic Health, Centre for Cell and Chromosome Biology, Brunel University, Uxbridge UB8 3PH, U.K.
1To whom correspondence should be addressed (email Joanna.Bridger@brunel.ac.uk).
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Publisher: Portland Press Ltd
Received:
July 08 2008
Online ISSN: 1470-8752
Print ISSN: 0300-5127
© The Authors Journal compilation © 2008 Biochemical Society
2008
Biochem Soc Trans (2008) 36 (6): 1378–1383.
Article history
Received:
July 08 2008
Citation
Lauren S. Elcock, Joanna M. Bridger; Exploring the effects of a dysfunctional nuclear matrix. Biochem Soc Trans 1 December 2008; 36 (6): 1378–1383. doi: https://doi.org/10.1042/BST0361378
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