1887

Abstract

A cotton rat () model of human parainfluenza virus type 3 (HPIV-3) infection was used to study patterns of HPIV-3 replication in naive and immune hosts. Growth curves revealed that nasal and pulmonary tissues of naive animals were semi-permissive for virus replication, with amounts of progeny virus proportional to inoculating doses. In naive animals there was a total eclipse in nasal tissues beginning 4 h after inoculation. By contrast, there was only partial eclipse of virus in pulmonary tissues, most pronounced at 1 h after inoculation. Immune animals demonstrated a delayed eclipse in pulmonary tissues upon rechallenge. Infection with very low doses of HPIV-3 induced complete protection against high-dose challenge in the absence of systemic neutralizing antibody, suggesting a significant role for other systemic or local immune effectors.

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1996-08-01
2024-04-27
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References

  1. Brideau R. J., Oien N. L., Lehman D. J., Homa F. L., Wat hen M. W. 1993; Protection of cotton rats against human parainfluenza virus type 3 by vaccination with a chimeric FHN subunit glycoprotein. Journal of General Virology 74:471–477
    [Google Scholar]
  2. British Public Health Laboratory Service Communicable Disease Surveillance Centre 1983; Parainfluenza infections in the elderly 1976–82. British Medical Journal 287:1619
    [Google Scholar]
  3. Ginsberg H. S. Jr, Horsfall F. L. 1952; Quantitative aspects of the multiplication of influenza A virus in the mouse lung. Relation between the degree of viral multiplication and the extent of pneumonia. Journal of Experimental Medicine 95:135–145
    [Google Scholar]
  4. Heidemann S. M. 1992; Clinical characteristics of parainfluenza virus infection in hospitalized children. Pediatric Pulmonology 13:86–89
    [Google Scholar]
  5. Homa F. L., Brideau R. J., Lehman D. J., Thomsen D. R., Olmsted R. A., Wathen M. W. 1993; Development of a novel subunit vaccine that protects cotton rats against both human respiratory syncytial virus and human parainfluenza virus type 3. Journal of General Virology 74:1995–1999
    [Google Scholar]
  6. Horsfall F. L., Ginsberg H. S. 1951; The dependence of the pathological lesion upon the multiplication of pneumonia virus of mice (PVM). Kinetic relation between the degree of viral multiplication and the extent of pneumonia. Journal of Experimental Medicine 93:139–150
    [Google Scholar]
  7. Johnson S. A., Ottolini M. G., Darnell M. E. R., Porter D. D., Prince G. A. 1996; Unilateral nasal infection of cotton rats with respiratory syncytial virus allows assessment of local and systemic immunity. Journal of General Virology 77:101–108
    [Google Scholar]
  8. Knott A. M., Long C. E., Hall C. B. 1994; Parainfluenza viral infections in pediatric outpatients: seasonal patterns and clinical characteristics. Pediatric Infectious Disease Journal 13:269–273
    [Google Scholar]
  9. Lehman D. J., Roof L. L., Brideau R. J., Aeed P. A., Thomsen D. R., Elhammer A. P., Wathen M. W., Homa F. L. 1993; Comparison of soluble and secreted forms of human parainfluenza virus type 3 glycoproteins expressed from mammalian and insect cells as subunit vaccines. Journal of General Virology 74:459–469
    [Google Scholar]
  10. Murphy T. F., Dubovi E. J. Jr, Clyde W. A. 1981; The cotton rat as an experimental model of human parainfluenza virus type 3 disease. Experimental Lung Research 2:97–109
    [Google Scholar]
  11. Porter D. D., Prince G. A., Hemming V. G., Porter H. G. 1991; Pathogenesis of human parainfluenza virus 3 infection in two species of cotton rats: Sigmodon hispidus develops bronchiolitis, while Sigmodon fulviventer develops interstitial pneumonia. Journal of Virology 65:103–111
    [Google Scholar]
  12. Prince G. A., Hemming V. G., Horswood R. L., Chanock R. M. 1985; Immunoprophylaxis and immunotherapy of respiratory syncytial virus in the cotton rat. Virus Research 3:193–206
    [Google Scholar]
  13. Sami I. R., Piazza F. M., Johnson S. A., Darnell M. E. R., Ottolini M. G., Hemming V. G., Prince G. A. 1995; Systemic immunoprophylaxis of nasal respiratory syncytial virus infection in cotton rats. Journal of Infectious Diseases 171:440–443
    [Google Scholar]
  14. Spriggs M. K., Murphy B. R., Prince G. A., Olmsted R. A., Collins P. L. 1987; Expression of the F and HN glycoproteins of human parainfluenza virus type 3 by recombinant vaccinia viruses: contributions of the individual proteins to host immunity. Journal of Virology 61:3416–3423
    [Google Scholar]
  15. van Wyke Coelingh K. L., Murphy B. R., Collins P. L., Lebacq-Verheyden A. -M., Battey J. F. 1987; Expression of biologically active and antigenically authentic parainfluenza type 3 virus hemagglutinin-neuraminidase glycoprotein by a recombinant baculo-virus. Virology 160:465–472
    [Google Scholar]
  16. Wendt C. H., Weisdorf D. J., Jordan M. C., Balfour H. H., Hertz M. I. 1992; Parainfluenza virus respiratory infection after bone marrow transplantation. New England Journal of Medicine 326:921–926
    [Google Scholar]
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