Long-range Intron-Exon and Intron-Intron Pairings Involved in Self-splicing of Class II Catalytic Introns
- F. Michel and
- A. Jacquier
This extract was created in the absence of an abstract.
Excerpt
Secondary structure models for the two unrelated families of organelle introns were proposed in 1982 (Michel et al. 1982; for class I, see Davies et al. 1982). Shortly afterward, the Tetrahymena self-splicing intervening sequence was recognized as a typical member of class I (Burke and RajBhandary 1982; Cech et al. 1983; Michel and Dujon 1983; Waring et al. 1983), and speculation on the possible catalytic properties of its organelle counterparts began.
The 1982 models were based on a small number of sequences, and the model for class II was regarded as merely tentative, having been deduced from the comparison of only two sequences. Nevertheless, both the class I and class II original models have successfully withstood the test of time, for all subsequently determined sequences readily lent themselves to secondary structure modeling when the set of “rules” proposed in the 1982 papers was followed (for review of the evidence for...
