Insulin and Insulin-like Growth Factor Receptors and Responses
This extract was created in the absence of an abstract.
Excerpt
Insulin is a member of a family of structurally related hormones with diverse physiological functions. The basic structure of these molecules is present even in hormones isolated from invertebrates (Thorpe and Duve 1988). In humans, the best-characterized members of this family include insulin, insulin-like growth factor (IGF)-I, and IGF-II. The physiological role of insulin is primarily to regulate rapid anabolic responses, such as glucose uptake into muscle and fat cells (Rosen 1987). IGF-I, on the other hand, appears to be primarily involved in regulating a long-term response, the growth of an organism (Rechler et al. 1987). The physiological role(s) of the third member of this family, IGF-II, is not known.
Each of these three polypeptide hormones has its own distinct receptor. The structures of each of these receptors have now been deduced from analyses of isolated cDNA clones (Ebina et al. 1985; Ullrich et al. 1985, 1986; Morgan et al....
