Insulin Mediators: Structure and Formation

  1. J. Larner*,
  2. L.C. Huang*,
  3. G. Tang*,
  4. S. Suzuki*,
  5. C.F.W. Schwartz*,
  6. G. Romero*,
  7. Z. Roulidis*,
  8. K. Zeller*,
  9. T. Y. Shen,
  10. A.S. Oswald, and
  11. L. Luttrell*
  1. Departments of *Pharmacology, and Chemistry, University of Virginia School of Medicine, Charlottesville, Virginia 22908

This extract was created in the absence of an abstract.

Excerpt

In two previous papers (Larner et al. 1979b, 1981), we have described our work on the mechanism of insulin action to control glycogen synthesis via the generation of mediators that control the covalent phosphorylation state. Several laboratories have continued a series of intensive investigations aimed at elucidating insulin's mechanism of action. These have included studies on the insulin receptor tyrosine kinase activity, activation of serine protein kinases by insulin, and the formation of insulin mediators as potential portions of insulin's signaling pathway.

In this paper, we consider the structure and formation of insulin mediators, including our data which indicate that mediators arise from the external surface of the cell. Since this paper is essentially in the nature of a review, the reader is referred to specific referenced papers for the methodology that has been utilized by our laboratory and others.

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