eyelidantagonizes wingless signaling during Drosophiladevelopment and has homology to the Bright family of DNA-binding proteins

  1. Jessica E. Treisman1,2,4,
  2. Alvin Luk3,
  3. Gerald M. Rubin2, and
  4. Ulrike Heberlein3
  1. 1Skirball Institute of Biomolecular Medicine, NYU Medical Center, New York, New York 10016 USA; 2Howard Hughes Medical Institute (HHMI) and Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720 USA; 3Gallo Center and Department of Neurology, Programs in Neuroscience and Developmental Biology, University of California at San Francisco, San Francisco General Hospital, San Francisco, California 94110 USA

Abstract

In Drosophila, pattern formation at multiple stages of embryonic and imaginal development depends on the same intercellular signaling pathways. We have identified a novel gene, eyelid(eld), which is required for embryonic segmentation, development of the notum and wing margin, and photoreceptor differentiation. In these tissues, eld mutations have effects opposite to those caused by wingless (wg) mutations.eld encodes a widely expressed nuclear protein with a region homologous to a novel family of DNA-binding domains. Based on this homology and on the phenotypic analysis, we suggest that Eld could act as a transcription factor antagonistic to the Wg pathway.

Keywords

Footnotes

  • 4 Corresponding author.

  • E-MAIL treisman{at}saturn.med.nyu.edu; FAX (212) 263-7760.

    • Received April 18, 1997.
    • Accepted June 5, 1997.
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