Proteasomal regulation of nuclear receptor corepressor-mediated repression
Abstract
Repression of gene transcription is a fundamental property of nuclear hormone receptors. We report here that cell-specific repression by nuclear receptors correlates with levels of nuclear receptor corepressor (N-CoR) protein. N-CoR protein levels are regulated by mSiah2, a mammalian homolog of Drosophila Seven in absentiathat targets N-CoR for proteasomal degradation. mSiah2 expression is cell-type specific and differentially regulates the repressive activities of nuclear receptors. These findings establish targeted proteolysis of transcriptional coregulators as a mechanism for cell-specific regulation of gene transcription.
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Footnotes
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↵3 Corresponding author.
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E-MAIL lazar{at}mail.med.upenn.edu; FAX (215) 898-5408.
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- Received January 13, 1998.
- Accepted April 17, 1998.
- Cold Spring Harbor Laboratory Press