Small RNA guides for de novo DNA methylation in mammalian germ cells
Abstract
Germline genomic methylation is essential for gamete identity and integrity in mammals. The study by Kuramochi-Miyagawa and colleagues (908–917) in the previous issue of Genes & Development links the process of DNA methylation-dependent repression of retrotranspons with the presence of piwi-interacting RNAs (piRNAs) in fetal male germ cells undergoing de novo methylation.
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Footnotes
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↵3 Corresponding author.
↵3 E-MAIL bourchis{at}ijm.jussieu.fr; FAX 33-1-44-27-82-10.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1669408.
- Copyright © 2008, Cold Spring Harbor Laboratory Press