The origin of embryonic and fetal myoblasts: a role of Pax3 and Pax7
- Division of Regenerative Medicine, San Raffaele Scientific Institute, Milan 20132, Italy; Department of Biology, University of Milan, Milan 20122, Italy
Abstract
Skeletal muscle is a heterogeneous tissue composed of individual muscle fibers, diversified in size, shape, and contractile protein content, to fulfill the different functional needs of the vertebrate body. This heterogeneity derives from and depends at least in part on distinct classes of myogenic progenitors; i.e., embryonic and fetal myoblasts and satellite cells whose origin and lineage relationship have been elusive so far. In this issue of Genes & Development, Hutcheson and colleagues (pp. 997–1013) provide a first answer to this question.
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↵1 Corresponding author.
↵E-MAIL cossu.giulio{at}hsr.it; FAX 390226434621.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1797009.
- Copyright © 2009 by Cold Spring Harbor Laboratory Press