The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis
Abstract
Differentiation of multipotent stem cells occurs through the highly coordinated control of gene expression. Repressor element 1 (RE1) silencing transcription factor (REST), a master transcriptional regulator in neuronal stem cells, restricts neuronal gene expression. REST activity is context-dependent and is modified by its cofactors, such as Ctdsp2. In this issue of Genes & Development, Dill and colleagues (pp. 25–30) report on the microRNA-mediated regulation of neural differentiation. Interestingly, this microRNA is post-transcriptionally regulated and modulates expression of its host gene, ctdsp2.
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↵1 Corresponding author.
E-mail gage{at}salk.edu.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.184416.111.
- Copyright © 2012 by Cold Spring Harbor Laboratory Press
