Zebrafish genetics gets the Scube on Hedgehog secretion
Abstract
Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312–1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins in this process.
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↵1 Correspondence
E-mail pingham{at}imcb.a-star.edu.sg
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.207126.112.
- Copyright © 2012 by Cold Spring Harbor Laboratory Press