Zebrafish genetics gets the Scube on Hedgehog secretion

  1. Philip W. Ingham1
  1. Institute of Molecular and Cell Biology (IMCB), Singapore 138673, Singapore

    Abstract

    Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312–1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins in this process.

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