The family that eats together stays together: new p53 family transcriptional targets in autophagy

  1. Elsa R. Flores1,2,3
  1. 1Department of Biochemistry and Molecular Biology,
  2. 2Graduate School of Biomedical Science, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA

    Abstract

    Autophagy is a biological process that is crucial to maintain cellular homeostasis and is regulated by several metabolic pathways, including the p53 tumor suppressor pathway. In this issue of Genes & Development, Kenzelmann Broz and colleagues (pp. 1016–1031) show how the p53 family as a whole, including p63 and p73, collaborate in controlling autophagy to support tumor suppression.

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    Related Article

    • RESEARCH PAPER: Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses
      • Daniela Kenzelmann Broz,
      • Stephano Spano Mello,
      • Kathryn T. Bieging,
      • Dadi Jiang,
      • Rachel L. Dusek,
      • Colleen A. Brady,
      • Arend Sidow,
      • and Laura D. Attardi
      Genes Dev. May 1, 2013 27: 1016-1031; doi:10.1101/gad.212282.112
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    1. doi: 10.1101/gad.219147.113 Genes & Dev. 27: 971-974 Copyright © 2013 by Cold Spring Harbor Laboratory Press

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