The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc-dependent oncogenesis

  1. Jeonghyeon Park1,
  2. Sudeesha Kunjibettu2,
  3. Steven B. McMahon2, and
  4. Michael D. Cole1,3
  1. 1Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, Princeton, New Jersey 08544-1014, USA; 2The Wistar Institute, Philadelphia, Pennsylvania 19104-4268, USA

Abstract

The ATM-related TRRAP protein is a component of several different histone acetyltransferase (HAT) complexes but lacks the kinase activity characteristic of other ATM family members. We identified a novel function for this evolutionarily conserved domain in its requirement for the assembly of a functional HAT complex. Ectopic expression of TRRAP protein with a mutation in the ATM-related domain inhibits Myc-mediated oncogenic transformation. The Myc-binding region of TRRAP maps to a separable domain, and ectopic expression of this domain inhibits cell growth. These findings demonstrate that the ATM-related domain of TRRAP forms a structural core for the assembly and recruitment of HAT complexes by transcriptional activators.

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Footnotes

  • ↵3 Corresponding author.

  • E-MAIL mcole{at}molbio.princeton.edu; FAX (609) 258-4575.

  • Article and publication are at http://www.genesdev.org/cgi/doi/10.1101/gad.900101.

    • Received March 30, 2001.
    • Accepted May 14, 2001.
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  1. doi: 10.1101/gad.900101 Genes & Dev. 15: 1619-1624 Cold Spring Harbor Laboratory Press

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