GABA-mediated presynaptic inhibition is required for precision of long-term memory
Abstract
Though much attention has been given to the neural structures that underlie the long-term consolidation of contextual memories, little is known about the mechanisms responsible for the maintenance of memory precision. Here, we demonstrate a rapid time-dependent decline in memory precision in GABAB(1a) receptor knockout mice. First, we show that GABAB(1a) receptors are required for the maintenance, but not encoding, of a precise fear memory. We then demonstrate that GABAB(1a) receptors are required for the maintenance, but not encoding, of spatial memories. Our findings suggest that GABA-mediated presynaptic inhibition regulates the maintenance of memory precision as a function of memory age.
Footnotes
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↵1 Corresponding author
E-mail ajasnow{at}kent.edu
- Received August 27, 2013.
- Accepted January 7, 2014.
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