Do Higher-Order Chromatin Structure and Nuclear Reorganization Play a Role in Regulating Hox Gene Expression during Development?
This extract was created in the absence of an abstract.
Excerpt
It is quite clear that nucleosome structure affects geneexpression and contributes to epigenetic inheritance ofgene expression states. The best understood examples arethe correlations of histone acetylation and methylation toeither active transcription or gene repression (Fischle etal. 2003). There is a growing realization that variant histones, such as histones H2A.Z and H3.3, are also criticalin demarcating active and silent chromatin (Meneghini etal. 2003; McKittrick et al. 2004). But can all epigeneticinformation about gene expression be accounted for bychromatin structure at the level of the nucleosome and itsmodifications, or could poorly understood higher-orderchromatin structures and nuclear organization also have arole? To answer this question we have focused here onchromatin and nuclear structure at the murine HoxB locus...
