Role of the Nuclear Lamina in Genome Organization and Gene Expression

  1. B. van Steensel
  1. Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands
  1. Correspondence: b.v.steensel{at}nki.nl

Abstract

The nuclear lamina is a major structural component of metazoan nuclei that has long been thought to provide an anchoring site for interphase chromosomes and have a role in gene regulation. Recent genome-wide mapping studies and functional experimental data strongly support these roles of the nuclear lamina. Here, we discuss new insights into various aspects of genome–nuclear lamina interactions, with emphasis on the links with gene regulation and with dynamics during cellular differentiation.

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