Ubiquitination and Degradation of the Inhibitors of NF-κB
- Departments of Immunology and Genetics and Biotechnology, Hebrew University-Hadassah Medical School, Institute of Medical Research Israel-Canada, Jerusalem, 91120, Israel
- Correspondence: yinon{at}cc.huji.ac.il
Abstract
The key step in NF-κB activation is the release of the NF-κB dimers from their inhibitory proteins, achieved via proteolysis of the IκBs. This irreversible signaling step constitutes a commitment to transcriptional activation. The signal is eventually terminated through nuclear expulsion of NF-κB, the outcome of a negative feedback loop based on IκBα transcription, synthesis, and IκBα-dependent nuclear export of NF-κB (Karin and Ben-Neriah 2000). Here, we review the process of signal-induced IκB ubiquitination and degradation by comparing the degradation of several IκBs and discussing the characteristics of IκBs’ ubiquitin machinery.
Footnotes
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Editors: Louis M. Staudt and Michael Karin
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Additional Perspectives on NF-κB available at www.cshperspectives.org
- Copyright © 2010 Cold Spring Harbor Laboratory Press; all rights reserved
