Shared and unique properties of ubiquitin and SUMO interaction networks in DNA repair
- 1Institute of Biochemistry II, Goethe University School of Medicine, 60590 Frankfurt am Main, Germany;
- 2Frankfurt Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt am Main, Germany
Abstract
In this issue of Genes & Development, Yang and colleagues (pp. 1847–1858) identify new components of a small ubiquitin-like modifier (SUMO)-like interaction network that orchestrates and fine-tunes the Fanconi anemia (FA) pathway and replication-coupled repair. This new pathway emphasizes the intricate interplay of ubiquitin (Ub) and SUMO networks in the DNA damage response.
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↵3 Corresponding author.
E-mail Ivan.Dikic{at}biochem2.de.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.17593511.
- Copyright © 2011 by Cold Spring Harbor Laboratory Press
