A wheel of time: the circadian clock, nuclear receptors, and physiology
- Program in Integrative Cell Signaling and Neurobiology of Metabolism, Section of Comparative Medicine, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Abstract
It is a long-standing view that the circadian clock functions to proactively align internal physiology with the 24-h rotation of the earth. Recent studies, including one by Schmutz and colleagues (pp. 345–357) in the February 15, 2010, issue of Genes & Development, delineate strikingly complex connections between molecular clocks and nuclear receptor signaling pathways, implying the existence of a large-scale circadian regulatory network coordinating a diverse array of physiological processes to maintain dynamic homeostasis.
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↵1 Correspondence.
E-MAIL xiaoyong.yang{at}yale.edu; FAX (203) 785-7499.
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Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.1920710.
- Copyright © 2010 by Cold Spring Harbor Laboratory Press
