Addicted to Myc—but why?

Björn von Eyss; Martin Eilers

doi:10.1101/gad.2053311

Addicted to Myc—but why?

Björn von Eyss and
Martin Eilers 1

Theodor Boveri Institute, Biocenter, University of Würzburg, Würzburg 97074, Germany

Abstract

Many tumors continuously depend on the initiating oncogenes, but whether this extends to their downstream targets is unclear. In this issue of Genes & Development, Sodir and colleagues (pp. 907–916) demonstrate an essential role for endogenous Myc proteins in maintaining the tumor microenvironment, providing an unexpected molecular explanation for addiction to Myc.

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Footnotes

↵1 Corresponding author.

E-MAIL martin.eilers{at}biozentrum.uni-wuerzburg.de; FAX 49-9031-3184113.
Article is online at http://www.genesdev.org/cgi/doi/10.1101/gad.2053311.