A Mouse Model of Congenital Heart Disease: Cardiac Arrhythmias and Atrial Septal Defect Caused by Haploinsufficiency of the Cardiac Transcription Factor Csx/Nkx2.5
- M. TANAKA,
- C.I. BERUL,
- M. ISHII,
- P.Y. JAY,
- H. WAKIMOTO,
- P. DOUGLAS,
- N. YAMASAKI,
- T. KAWAMOTO,
- J. GEHRMANN,
- C.T. MAGUIRE,
- M. SCHINKE,
- C.E. SEIDMAN,
- J.G. SEIDMAN,
- Y. KURACHI, and
- S. IZUMO
- *Cardiovascular Division, Beth Israel Deaconess Medical Center, and Department of Medicine, †Department of Cardiology, Children's Hospital, §Department of Genetics, Howard Hughes Medical Institute; **Cardiovascular Division, Howard Hughes Medical Institute, Brigham and Women's Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215; ‡Department of Pharmacology, Graduate School of Medicine, Osaka University, Osaka, Japan; ¶Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
This extract was created in the absence of an abstract.
Excerpt
Congenital heart disease (CHD) is the most commonbirth defect in humans, affecting ~8 per 1000 live births(Friedman 1997). More children die from CHD than fromall childhood malignancies combined. However, themolecular mechanisms underlying CHD are largely unknown...
