Finite-size effects on long-range correlations: Implications for analyzing DNA sequences

C.-K. Peng, S. V. Buldyrev, A. L. Goldberger, S. Havlin, M. Simons, and H. E. Stanley
Phys. Rev. E 47, 3730 – Published 1 May 1993
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Abstract

We analyze the fluctuations in the correlation exponents obtained for noncoding DNA sequences. We find prominent sample-to-sample variations as well as variations within a single sample in the scaling exponent. To determine if these fluctuations may result from finite system size, we generate correlated random sequences of comparable length and study the fluctuations in this control system. We find that the DNA exponent fluctuations are consistent with those obtained from the control sequences having long-range power-law correlations. Finally, we compare our exponents for the DNA sequences with the exponents obtained from power-spectrum analysis and correlation-function techniques, and demonstrate that the original ‘‘DNA-walk’’ method is intrinsically more accurate due to reduced noise.

  • Received 14 December 1992

DOI:https://doi.org/10.1103/PhysRevE.47.3730

©1993 American Physical Society

Authors & Affiliations

C.-K. Peng and S. V. Buldyrev

  • Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215

A. L. Goldberger

  • Cardiovascular Division, Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215

S. Havlin

  • Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215

M. Simons

  • Cardiovascular Division, Harvard Medical School, Beth Israel Hospital, Boston Massachusetts 02215
  • Biology Department, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

H. E. Stanley

  • Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215

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Vol. 47, Iss. 5 — May 1993

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