Statistical correlation of nucleotides in a DNA sequence

Liaofu Luo; Weijiang Lee; Lijun Jia; Fengmin Ji; Lu Tsai

doi:10.1103/PhysRevE.58.861

Statistical correlation of nucleotides in a DNA sequence

Liaofu Luo, Weijiang Lee, Lijun Jia, Fengmin Ji, and Lu Tsai

Phys. Rev. E 58, 861 – Published 1 July 1998

Abstract

We review methods in the study of nucleotide correlation in DNA sequence, and demonstrate two basic properties of the correlation through statistical analysis, namely, the short-range dominance of nucleotide correlation in most DNA sequences and the coarse-grained evolutionary dependence of the short-range correlation in coding sequences. A corresponding evolutionary mechanism is suggested. By the use of spectral analysis a large inhomogeneity in long-range base correlations for different sequences is indicated. Some results on three-dimensional DNA walks are reported. The linguistic differences between coding and noncoding sequences are also indicated.

Received 26 November 1997

DOI:https://doi.org/10.1103/PhysRevE.58.861

Authors & Affiliations

Liaofu Luo^*

Department of Physics, Inner Mongolia University, Hohhot 010021, China

Weijiang Lee^†

CCAST (World Laboratory), P.O. Box 8730, Beijing 100080, China
Department of Physics, Inner Mongolia University, Hohhot 010021, China

Lijun Jia, Fengmin Ji, and Lu Tsai

Department of Physics, Inner Mongolia University, Hohhot 010021, China

^*Author to whom correspondence should be addressed. Electronic address: lfluo@nmg2.imu.edu.cn
^†Permanent address: Department of Physics, Inner Mongolia University, Hohhot 010021, China.

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Vol. 58, Iss. 1 — July 1998

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Physical Review E

covering statistical, nonlinear, biological, and soft matter physics