Phys. Rev. E 71, 011902 (2005) - Optimal path to epigenetic switching

Optimal path to epigenetic switching

David Marin Roma, Ruadhan A. O’Flanagan, Andrei E. Ruckenstein, Anirvan M. Sengupta, and Ranjan Mukhopadhyay

Phys. Rev. E 71, 011902 – Published 11 January 2005

Abstract

We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.

Received 6 June 2004

DOI:https://doi.org/10.1103/PhysRevE.71.011902

©2005 American Physical Society

Authors & Affiliations

David Marin Roma, Ruadhan A. O’Flanagan, Andrei E. Ruckenstein, and Anirvan M. Sengupta

Department of Physics and Astronomy and BioMaPS Institute, Rutgers University, Piscataway, New Jersey 08854, USA

Ranjan Mukhopadhyay

Department of Physics, Clark University, Worcester, Massachusetts 01610, USA

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Issue

Vol. 71, Iss. 1 — January 2005

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