Error Threshold for Spatially Resolved Evolution in the Quasispecies Model

S. Altmeyer and J. S. McCaskill
Phys. Rev. Lett. 86, 5819 – Published 18 June 2001
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Abstract

The error threshold for quasispecies in 1, 2, 3, and dimensions is investigated by stochastic simulation and analytically. The results show a monotonic decrease in the maximal sustainable error probability with decreasing diffusion coefficient, independently of the spatial dimension. It is thereby established that physical interactions between sequences are necessary in order for spatial effects to enhance the stabilization of biological information. The analytically tractable behavior in an -dimensional (simplex) space provides a good guide to the spatial dependence of the error threshold in lower dimensional Euclidean space.

  • Received 6 July 2000

DOI:https://doi.org/10.1103/PhysRevLett.86.5819

©2001 American Physical Society

Authors & Affiliations

S. Altmeyer and J. S. McCaskill

  • Biomolecular Information Processing, BioMIP, GMD-German National Research Center for Information Technology, Schloss Birlinghoven, 53754 St. Augustin, Germany

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Issue

Vol. 86, Iss. 25 — 18 June 2001

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