In Vivo Anomalous Diffusion and Weak Ergodicity Breaking of Lipid Granules

Jae-Hyung Jeon, Vincent Tejedor, Stas Burov, Eli Barkai, Christine Selhuber-Unkel, Kirstine Berg-Sørensen, Lene Oddershede, and Ralf Metzler
Phys. Rev. Lett. 106, 048103 – Published 25 January 2011
PDFHTMLExport Citation

Abstract

Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.

  • Figure
  • Figure
  • Figure
  • Figure
  • Received 2 October 2010

DOI:https://doi.org/10.1103/PhysRevLett.106.048103

© 2011 American Physical Society

Authors & Affiliations

Jae-Hyung Jeon1, Vincent Tejedor2, Stas Burov3, Eli Barkai3, Christine Selhuber-Unkel4,5, Kirstine Berg-Sørensen6, Lene Oddershede4, and Ralf Metzler1,7

  • 1Physics Department T30g, Technical University of Munich, 85747 Garching, Germany
  • 2Physique Théorique de la matiére condensée, Université Pierre et Marie Curie, 4 place Jussieu, 75252 Paris, France
  • 3Physics Department, Bar-Ilan University, Ramat Gan 52900, Israel
  • 4Niels Bohr Institute, Blegdamsvej 17, 2100 København Ø, Denmark
  • 5Institute for Materials Science, University of Kiel, Kaiserstraße 2, 24143 Kiel, Germany
  • 6Physics Department, Technical University of Denmark, 2800 Kongens Lyngby, Denmark
  • 7Department of Physics, Tampere University of Technology, FI-33101 Tampere, Finland

Article Text (Subscription Required)

Click to Expand

Supplemental Material (Subscription Required)

Click to Expand

References (Subscription Required)

Click to Expand
Issue

Vol. 106, Iss. 4 — 28 January 2011

Reuse & Permissions
Access Options
Author publication services for translation and copyediting assistance advertisement

Authorization Required


×
×

Images

×

Sign up to receive regular email alerts from Physical Review Letters

Log In

Cancel
×

Search


Article Lookup

Paste a citation or DOI

Enter a citation
×