Role of reactive oxygen species in low level light therapy

Aaron Chi-Hao Chen; Ying-Ying Huang; Praveen R. Arany; Michael R. Hamblin

doi:10.1117/12.814890

18 February 2009 Role of reactive oxygen species in low level light therapy

Aaron Chi-Hao Chen, Ying-Ying Huang, Praveen R. Arany, Michael R. Hamblin

Proceedings Volume 7165, Mechanisms for Low-Light Therapy IV; 716502 (2009) https://doi.org/10.1117/12.814890
Event: SPIE BiOS, 2009, San Jose, California, United States

Abstract

This review will focus on the role of reactive oxygen species in the cellular and tissue effects of low level light therapy (LLLT). Coincidentally with the increase in electron transport and in ATP, there has also been observed by intracellular fluorescent probes and electron spin resonance an increase in intracellular reactive oxygen species (ROS) such as superoxide, hydrogen peroxide, singlet oxygen and hydroxyl radical. ROS scavengers, antioxidants and ROS quenchers block many LLLT processes. It has been proposed that light between 400-500- nm may produce ROS by a photosensitization process involving flavins, while longer wavelengths may directly produce ROS from the mitochondria. Several redox-sensitive transcription factors are known such as NF-kB and AP1, that are able to initiate transcription of genes involved in protective responses to oxidative stress. It may be the case that LLLT can be pro-oxidant in the short-term, but anti-oxidant in the long-term.

Citation Download Citation

Aaron Chi-Hao Chen, Ying-Ying Huang, Praveen R. Arany, and Michael R. Hamblin "Role of reactive oxygen species in low level light therapy", Proc. SPIE 7165, Mechanisms for Low-Light Therapy IV, 716502 (18 February 2009); https://doi.org/10.1117/12.814890

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