Abstract
Lysophosphatidic acid (LPA) is a simple bioactive phospholipid with diverse physiological actions on many cell types. LPA induces proliferative and/or morphological effects and has been proposed to be involved in biologically important processes including neurogenesis, myelination, angiogenesis, wound healing, and cancer progression. LPA acts through specific G protein-coupled, seven-transmembrane domain receptors. To date, three mammalian cognate receptor genes,lp A1/vzg-1/Edg2,lp A2/Edg4, andlp A3/Edg7, have been identified that encode high-affinity LPA receptors. Here, we review current knowledge on these LPA receptors, including their isolation, function, expression pattern, gene structure, chromosomal location, and possible physiological or pathological roles.
Footnotes
- Received July 14, 2000.
- Accepted September 20, 2000.
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Send reprint requests to: Dr. Jerold Chun, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Dr., La Jolla, CA. E-mail: jchun{at}ucsd.edu
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↵1 These authors contributed equally to this work.
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This work was supported by research grants from the National Institute of Mental Health (to J.J.A.C., J.C.) and the Uehara Memorial Foundation (to I.I.), and a sponsored research agreement with Allelix Biopharmaceuticals (to J.C.).
- The American Society for Pharmacology and Experimental Therapeutics
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