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Research Article Free access | 10.1172/JCI106895
Department of Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
Find articles by Gunn, R. in: JCI | PubMed | Google Scholar
Department of Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
Find articles by Silvers, D. in: JCI | PubMed | Google Scholar
Department of Physiology and Pharmacology, Duke University Medical Center, Durham, North Carolina 27710
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
Find articles by Rosse, W. in: JCI | PubMed | Google Scholar
Published May 1, 1972 - More info
The intracellular content of K+ in thalassemia minor red blood cells is markedly reduced after incubation in autologous serum for 24 hr at 37°C. There is no compensatory increase in intracellular Na+ concentration of the cell thus reduced. This change is due to an acquired increase in selective permeability of the membrane to K+. This phenomenon follows the depletion of energy sources in the thalassemia minor cells but does not follow comparable depletion in normal cells. The loss of osmotically active intracellular contents probably accounts for the increased resistance of incubated thalassemia minor red blood cells to osmotic lysis.
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