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Implementation of change in health care in Sweden: a qualitative study of professionals’ change responses

Abstract

Background

Implementation of evidence-based practices in health care implies change. Understanding health care professionals’ change responses may be critical for facilitating implementation to achieve an evidence-based practice in the rapidly changing health care environment. The aim of this study was to investigate health care professionals’ responses to organizational and workplace changes that have affected their work.

Methods

We conducted interviews with 30 health care professionals (physicians, registered nurses and assistant nurses) employed in the Swedish health care system. An inductive approach was applied, using a semi-structured interview guide developed by the authors. We used an analytical framework first published in 1999 to analyze the informants’ change responses in which change responses are perceived as a continuum ranging from a strong acceptance of change to strong resistance to change, describing seven forms of change responses along this continuum. Change response is conceptualized as a tridimensional attitude composed of three components: cognitive, affective and intentional/behavioral.

Results

Analysis of the data yielded 10 types of change responses, which could be mapped onto 5 of the 7 change response categories in the framework. Participants did not report change responses that corresponded with the two most extreme forms of responses in the framework, i.e., commitment and aggressive resistance. Most of the change responses were classified as either indifference or passive resistance to changes. Involvement in or support for changes occurred when the health care professionals initiated the changes themselves or when the changes featured their active input and when changes were seen as well founded and well communicated. We did not identify any change responses that could not be fitted into the framework.

Conclusions

We found the framework to be useful for a nuanced understanding of how people respond to changes. This knowledge of change responses is useful for the management of changes and for efforts to achieve more successful implementation of evidence-based practices in health care.

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Introduction

Change is pervasive in health care. Changing disease patterns, aging populations, new discoveries of treatment of diseases, technological advancements, political reforms, and policy initiatives place demands on health care organizations and professionals’ capacity to implement change [1,2,3,4]. Health care is facing a wave of new technologies and business models (e.g., telemedicine), which is likely essential if health care is to meet growing needs in areas such as chronic disease management. The patient experience is evolving into a broader patient experience as more patients are becoming involved in decisions about their care, pointing to patient/provider relationships based on partnership and mutual empowerment [5].

Changes within an organization are usually associated with employee psychological uncertainty about how the change will affect their lives [6, 7]. The demand to change has well-documented effects on employee health and well-being, as assessed by a range of indicators and constructs, e.g., work-related stress, mental health problems, change fatigue, poor self-rated health, adverse sleep patterns, sickness absence, hospital admissions, and stress-related medicine prescriptions [6, 8,9,10,11,12].

Health care professionals’ change responses may have important implications for the implementation of evidence-based practices in health care. Theories, models, and frameworks used in implementation science, as well as extant evidence, typically view health care professionals’ responses to the change associated with the implementation of a specific practice, e.g., a particular intervention, program or service. For example, the Consolidated Framework for Implementation Research [13] conceptualizes health care professionals’ change responses as their knowledge and beliefs about the implemented practice. Klein and Sorra [14] describe health care professionals’ responses to changes as the fit between evidence-based practice and health care professionals’ values (“innovation-values fit”). However, changes associated with implementing evidence-based practices represent only one type of change in health care due to the fast pace of change in this sector. Therefore, more general change responses, e.g., negative experiences from numerous and/or large organizational changes impacting health care professionals’ work, may be an important underlying influence on health care practitioners’ implementation intentions and behaviors.

Change responses have usually been described in terms of resistance to change, a concept which was introduced by Coch and French [15]. However, later conceptualizations have expanded beyond conceptualizations of resistance to change to encompass various degrees of acceptance (or readiness) for change, thus creating a continuum of change responses. Coetsee [16] describes seven forms of change responses, from aggressive resistance, active resistance and passive resistance to indifference, support, involvement, and commitment (please see further details in Table 1). Change response in the framework is conceptualized as a tridimensional attitude composed of three components: cognitive (opinions about changes, their usefulness, advantages and disadvantages, etc.), affective (feelings about changes), and intentional/behavioral (actions already taken or which will be taken for or against changes). This tridimensional concept of change response was proposed by Elizur and Guttman [17] and is widely used [18].

Table 1 Coetsee’s framework of change responses [16]

Understanding health care professionals’ change responses may be critical for facilitating implementation to achieve an evidence-based practice in the rapidly changing health care environment. However, responses to change in health care remain circumscribed in implementation theory, as described above, and poorly understood empirically. Hence, the aim of this study was to investigate health care professionals’ responses to organizational and workplace changes that have affected their work. We used Coetsee’s analytical framework to categorize different change responses. Knowledge of health care professionals’ change responses could be important to identify opportunities for promoting acceptance to change and limiting resistance to change inherent in the implementation of evidence-based practices in health care.

Methods

Study setting, design, and participants

We conducted interviews with 30 health care professionals (physicians, registered nurses, assistant nurses) employed in the Swedish health care system, which is mainly publicly funded although private health care also exists. All residents are insured by the state, with equal access for the entire population. Out-of-pocket fees are low and regulated by law.

We used a purposeful sampling strategy to achieve a heterogeneous sample of health care professionals working in different health care facilities in Sweden, ranging from primary care to hospital and tertiary care, with patients who varied in terms of health status and duration of stay. The aim was to achieve a sample of health care professionals that represented a broad spectrum of perceptions and experiences concerning changes in health care.

We recruited health care professionals through an e-mail that briefly described the study. The e-mail request was sent to the manager of each work unit, with a request that they forward our request to physicians, registered nurses and assistant nurses. To those who responded, we then sent an informational letter describing the study. None declined involvement after receiving the information letter. We scheduled interviews at a time (between January and September 2018) and in a location of participants’ choosing where they could feel comfortable speaking honestly (e.g., office with a closed door).

Data collection

The data collection applied an inductive approach, using a semi-structured interview guide developed by the authors. We generated the questions based on the existing literature on organizational change and change reactions [16, 18, 19]. The questions concerned the participants’ experiences and perceptions of any changes that they considered to have affected their work, regardless of whether these changes were “objectively” large, e.g., a restructuring of the organization, or small, e.g., modification of an already existing documentation routine, covering both broader, more general changes and more specific examples of changes, e.g., merging of the informant’s work unit with another unit, changed work routines or tasks, introduction of new information technology systems and moving to new localities. We did not ask about specific changes or provide examples, but instead allowed the participants to discuss any organizational and workplace changes they considered to have relevance for their work. This conceptualization of change is based on the fact that every individual experience change in a unique way; the same change may be attractive and imply advantages for some and be a source of stress and disadvantages for others [18].

We pilot-tested the questions in two interviews with regard to meaningfulness for participants and clarity of concepts. The pilot interviews indicated that the questions were generic enough to be used in different health care contexts, that the wording was clear, and that the interview did not exceed 60 min (which was deemed to be a maximum considering the participants’ work schedule). Individual interviews were conducted by all the authors except for SB, who does not speak Swedish, and were digitally recorded. Each interview lasted between 28 and 104 min, with an average of approximately 50 min. The interviews were transcribed verbatim by a professional transcription agency and were then inspected by the researcher who conducted the interview.

Before starting an interview the participant was asked to re-read the information letter and give a written informed consent to participate. Each interview began with some questions about the participant, the content of his or her work and some information about the workplace. This was followed by questions about what changes have taken place in the workplace, including the participant’s experiences and perceptions concerning the extent and nature of the changes and whether there was an increase or decrease over time. The participant was asked to provide examples of both successful and unsuccessful changes, from their perspective. We then asked questions about the participant’s response to the different changes. The interview guide ended with questions on potential and actual strategies to reduce negative health and well-being consequences of change and a final question concerning whether the participant had anything to add to what had been discussed.

Data analysis

We used the analytical framework by Coetsee [16] to analyze health care professionals’ change responses. Coetsee conceives change responses as a continuum ranging from a strong acceptance of the change to strong resistance to change. He describes seven forms of change responses along this continuum (Table 1).

To compare and contrast our study findings to the Coetsee framework, we began with qualitative content analysis, a technique for analysis of texts grounded in empirical data with an explorative and descriptive character [20]. As a first step, PN, CE, and KS read all transcripts to obtain an understanding of the whole. PN, CE, and KS then individually coded the transcripts using content analysis, which entails a structured analysis process to code and categorize the data. Next, we highlighted words in the text that captured various key statements and thoughts in relation to the study aim. We then aggregated the codes into clusters based on the similarity of the content and their relation to each other [21].

After re-examination in two group meetings, PN, CE, and KS merged the initial clusters into categories and labeled them [21]. We then cross-examined the categories to ascertain that they were defined in such a way that they were internally as homogeneous as possible and externally as heterogeneous as possible [20]. We then independently analyzed the data and compared our findings. Next, we mapped the categories onto the different types of response specified in the Coetsee framework, discussing our findings until we achieved no inconsistencies and a shared understanding [22].

PN, CE, and KS identified representative quotations for reporting. PN, who is fluent in English, then translated quotations from Swedish to English. PN, CE, and KS examined the quotations for accuracy. Finally, SB, whose first language is English, reviewed the English-language quotations for clarity.

Results

We conducted semi-structured individual interviews with 30 health care professionals: 11 physicians, 12 registered nurses and seven assistant nurses (Table 2). The participants were employed in 6 different health care units, all located in cities, with 67,000, 135,000, and 150,000 inhabitants, respectively, all located in the south-east part of Sweden.

Table 2 Participant characteristics

Analysis of the data yielded 10 types of change responses, numbered 1 to 10 below and in Table 3. The different types of responses could be mapped onto five of the seven change response categories in Coetsee’s framework [16]. Participants did not report change responses that corresponded with Coetsee’s two most extreme forms of responses, i.e., commitment and aggressive resistance. Several representative quotes for each type of change response are provided in Table 3.

Table 3 Participants’ change responses

Involvement in changes

(1) Involvement was the strongest form of support for changes expressed by the health care professionals. They provided numerous statements that suggested engagement in changes that were initiated by the health care professionals themselves or were characterized by their active input. They said that engagement was premised on changes that were “initiated by [themselves],” which would “emerge from the bottom up.” This engagement was not expressed in relation to top-down changes initiated by managers or politicians that lacked their own input. Rather, these changes generated “frustration” and were considered the “most problematic.”

Support for changes

(2) The health care professionals also expressed support for changes that they viewed as well founded because they could see the necessity or utility of the changes. The importance of having “an understanding” of why a change was made or prioritized was emphasized. In contrast, changes that were viewed as more or less pointless, e.g., not being “grounded in reality,” or appearing to be a waste of time and resources did not garner their support.

(3) Support was also expressed by the health care professionals for changes that they considered well communicated and predictable, which allowed them to prepare. This was summarized by one participant as “it’s all about information.” However, this support was not conveyed for changes that they did not receive sufficient information about. For example, one participant described being “in the dark” about a change. Similarly, health care professionals did not support changes that were perceived to be abrupt or unexpected.

Indifference to changes

(4) The health care professionals communicated change apathy, i.e., a state of indifference, when they talked about responses to many changes. This apathy manifested itself in numerous ways. Some health care professionals voiced a lack of interest, disengagement, or resignation in response to changes. They mentioned their “passivity” as well as being “resigned and tired” and not trying to “bother” with the changes.

(5) Many statements by the health care professionals indicated physical responses to changes such as exhaustion and weariness. Some talked about “tiredness” and not having “the stamina” to endure more changes. One participant even talked about suffering from “change fatigue syndrome.”

(6) Indifference also revealed itself in health care professionals’ emotional reactions to changes. They described negative emotions, including “very strong, very negative” feelings, “anxiety and a sense of insecurity.” These emotions generated anger and frustration, inducing stress. There was even a mention of “post-traumatic stress” as an emotional change response.

Passive resistance to changes

(7) Some statements by the health care professionals suggested passive resistance to changes. This revealed itself in voicing complaints and expressing dissatisfaction with changes by means of “too much whining.” The changes caused “many to curse, sigh” and they created “a lot of fuss and speculation.” These reactions seemed to spread and could “contaminate other people” in the work environment.

(8) Another expression of passive resistance among some health care professionals was to respond to changes by consciously reducing one’s own work efforts and ambitions. Participants mentioned that they would “try to do as little as possible” and work with “the least amount of effort” in response to changes.

(9) A few health care professionals also expressed passive resistance to changes by considering quitting their job in health care altogether, e.g., “thinking about retirement or doing something else.”

Active resistance to changes

(10) Some health care professionals responded to changes with active resistance by actively removing themselves from having to be involved in the changes in question. This was expressed by the participants in terms of trying “to avoid having anything to do” with the changes and refusing to “take [the changes] in.”

Discussion

Implementation of evidence-based practices in health care implies change [23]. In practice, health care professionals typically face many concurrent changes [24], and individuals’ responses to these changes vary [18].

We found Coetsee’s [16] change responses framework to be useful for a nuanced understanding of how people respond to changes, describing responses that range from a strong acceptance of the change to strong resistance to change. We identified in our study 10 types (i.e., sub-categories) of change responses, which could be mapped onto five of the seven response categories of Coetsee’s framework. We did not identify any change responses that could not be fit into the framework.

The participants did not report change responses that corresponded with Coetsee’s two most extreme forms of responses, i.e., Aggressive resistance and Commitment. The lack of change responses characterized by Aggressive resistance may be attributed to the Swedish workplace culture, including health care, which typically promotes stability and favors consensus over arguing or expressing strong emotions or opinions [25]. Commitment is a powerful acceptance of change which has been described by the willingness of employees to direct their energy and loyalty to the benefit of the organization to such an extent that a strong attachment is created to the values, goals, and vision of the organization [26, 27]. The lack of statements that conveyed this type of change response can be explained with reference to the overall paucity of examples of change responses categorized as involvement or support, i.e., the two less enthusiastic forms of change acceptance. These findings suggest that health care professionals are insufficiently engaged in efforts to solicit their commitment, which means that it may be unrealistic to expect a strong commitment from health care professionals when implementing change, including evidence-based practices.

The two forms of change acceptance we identified, involvement and support, were generally associated with changes that were initiated by the health care professionals themselves or featured their active input, changes they viewed as well-founded because they could see the utility of the changes or changes they considered well communicated and predictable. These findings are in line with previous organizational research which shows that resistance to change is more likely if employees consider a change initiative pointless and do not have a say in the planning or implementation of the change, while acceptance of change is more likely if they consider the change to be sensible and respect the individuals behind the change initiative [19]. How change is carried out is important, with open strains of communication and leadership that is perceived as competent and truthful in its implementation of change increasing the chances of change acceptance [18]. In line with this, research has demonstrated that organizational changes cause stress when changes create uncertainty (e.g., [28, 29]), are poorly communicated (e.g., [30]), are considered unfair (e.g., [31, 32]), and take place too quickly or too slowly (e.g., [32]).

Organizational theorists have acknowledged that sense-making processes are essential to understanding individuals’ responses to change [24, 33]. Interestingly, the characteristics of changes associated with involvement and support are consistent with Antonovsky’s sense of coherence theory [34], which can be applied at different system levels, from the individual to the societal level. The theory posits that we constantly are exposed to changes that function as stressors. A sense of coherence, therefore, reflects a coping capacity to deal with stressors and consists of comprehensibility, manageability, and meaningfulness. Changes which are seen as well founded, well communicated, and predictable are likely viewed as comprehensible, changes that are initiated by health care professionals or involve their active input are perceived as manageable, and changes seen as well founded are considered meaningful. The sense of coherence concept has been applied in many studies, e.g., concerning stress, burnout, and working circumstances [35], but to our knowledge the three elements of comprehensibility, manageability, and meaningfulness have not been applied in organizational research to provide understanding of why certain changes might be more successful than others. Further research is warranted to explore the extent to which implementation of evidence-based practices are perceived as comprehensible, manageable and meaningful. Future research should also assess the influence of variables such as involvement in planning, quality of communication regarding changes, and perceived relevance of changes on change responses. Research is also needed to find out whether these conditions have an additive or interactive effect on commitment.

Three of the 10 types of change responses were mapped onto the indifference category. This is considered a zone between acceptance and rejection of change in Coetsee’s framework, characterized by neutral cognitive and affective responses and passively resigned behaviors. Change apathy seemed to be a particularly common response to changes among health care professionals who had previously experienced changes impacting on their work which they considered unsuccessful. The organizational literature usually purports, with some empirical support, that 70% of all organizational change initiatives are failures [36]. Perceiving many organizational and workplace change initiatives as unsuccessful can yield change cynicism [37], which represents feelings that often combine pessimism about the likelihood of successful change with the blame of those responsible for change as incompetent [38]. Change cynicism appears to be a reaction to experiences from within an organization rather than being a general characteristic or trait [7]. Health care professionals who experience change cynicism are unlikely to have positive responses to changes involving the implementation of evidence-based practices.

Another sub-category of indifference, physical responses were described in terms of tiredness or change fatigue, which is exhaustion associated with feelings of being drained and depleted beyond one’s capacity to handle workplace demands and everyday work tasks [39, 40]. Change fatigue is different from various forms of change resistance since the behaviors are often passive, whereas change resistance behaviors are intentional. With change fatigue, individuals become disengaged and do not express their dissent about changes. Because of this passive behavior, change fatigue often is undetected by managers and leaders in organizations [41]. Research suggests that new graduate health care professionals and professionals newly transferred to a unit are more vulnerable to change fatigue [42]. Implementation of evidence-based practices in settings where change fatigue is prevalent can be expected to be difficult.

Physical responses seemed to be intertwined with emotional responses, with the health care professionals reporting a range of emotions, from anxiety and stress to frustration and anger. It is noteworthy that emotional change responses are not highlighted in descriptions of the Coetsee framework [16], but they clearly played an important role among the participants of this study. Emotional responses were only expressed in relation to change resistance and not with regard to change acceptance, i.e., involvement or support. It has been argued that affective aspects of change responses have been overlooked, although both theoretical and empirical studies point to the relevance of the affective element of attitudes [11]. This also has relevance for the implementation of evidence-based practices. For example, a Swedish study found that it was challenging to implement evidence-based palliative care in nursing homes as the desired behavior, providing existential care for the dying, was emotionally charged and presented difficulties even after the staff’s participation in educational interventions to acquire necessary skills and knowledge [43].

We also identified statements attributable to passive resistance. Resistance is the most studied response to change [44], being viewed as any set of intentions and actions that slows down or hinders the implementation of change [45]. Passive resistance revealed itself in reduced work effort, something which could potentially limit the effectiveness and efficiency of implemented evidence-based practices because policies and procedures may not be followed when delivering them, thus limiting their potential benefit. Implementation failure may result in type III error, i.e., attributing null results to an evidence-based practice’s inherent lack of effectiveness when, in actuality, the null results are due to implementation failure [46].

Passive resistance was also expressed in terms of health care professionals’ complaints about changes and thoughts about quitting the job in response to changes. Discontent was expressed by all three professional groups of the study, but physicians more often than registered nurses and assistant nurses complained about their working conditions. Although this response was passive, the participants described how negativity could spread and affect others, thus likely contributing to a culture of discontent that can have negative effects on the productivity.

Active resistance was expressed by some health care professionals who stayed away from changes or limited their involvement by trying to ignore the changes they did not want to be affected by. This “avoidance” strategy also seemed to be more common among the physicians than among the other professions.

Our findings concerning passive resistance and active resistance are aligned with research that has shown that physicians often are dissatisfied with their job, which can have negative consequences for their productivity, intent to leave the job, work ability, and amount of sick leave days [47,48,49]. The increased workload in combination with reduced autonomy has been identified as key sources of this dissatisfaction [50]. Physicians tend to be critical toward managerial control of their work [51,52,53] and are often reluctant to become involved in management-initiated quality improvement initiatives [4]. The central role of physicians for implementation of evidence-based practices in health care is well recognized, as they often act as informal leaders in daily health care practice, functioning both as change agents and gatekeepers to desired changes [54, 55].

Some methodological issues must be considered when interpreting the findings. A qualitative approach was chosen because little is known about change responses in Swedish health care. Interviews with physicians, registered nurses, and assistant nurses were considered the most relevant method for collecting information and gaining a deeper understanding of the topic. The change responses identified in this study are not intended as an exhaustive list of all possible responses; other studies may yield different responses or give different priorities to other factors. The results cannot be directly transferred to other health care settings in Sweden or internationally.

We used Coetsee’s [16] framework to analyze different change responses. According to De Casterle et al. [56], using a preconceived framework runs the risk of prematurely excluding alternative ways of organizing the data that may be more illuminating. However, we did not use Coetsee’s framework to inform the questions presented to the participants, and it was not applied until the second phase of the data analysis, after the data had first been analyzed inductively to arrive at change responses. Choosing one theory, model or framework often means placing weight on some aspects at the expense of others, thus offering only partial understanding [57]. However, Coetsee’s framework [16] was found to be sufficiently broad to allow for a fairly inductive approach. Some of the change response categories were difficult to distinguish from each other, including active and passive change responses although the former category involved taking some sort of action in response to changes whereas the latter category did not. We have sought other studies that may have applied Coetsee’s framework [16] to empirical studies, but we have not been able to find any. Given the usefulness of Coetsee’s framework for understanding change responses, we recommend that the framework be used in future implementation research on change responses.

The multidisciplinary research team was a strength of the study, because it permitted different perspectives on the issue of change responses in health care. The team consisted of the following professions: registered nurse (KS), behavioral scientist (CE), political scientist (IS), behavioral economist (PN), and organizational sociologist (SB). Another strength was the relatively high number of interviews. This allowed us to use quotations from many different participants, which added transparency and trustworthiness to the findings.

In terms of implications for implementation science, our study suggests that change responses may be an underlying explanation for some of the barriers for successful implementation of evidence-based practices often described in implementation research, e.g., lack of awareness, insufficient motivation, negative attitudes or ingrained habits among health care professionals [54]. Change responses may be associated with and/or influence implementation constructs such as receptive context for change [58], readiness for change [13] and tension for change [13, 58, 59], and optimism and beliefs about consequences and capabilities, as described in Theoretical Domains Framework [60]. Also, health care professionals’ change responses may be analogous to change commitment in the Organizational Readiness to Change theory [23]. Coetsee’s framework offers a nuanced way of understanding changes involved in implementation of evidence-based practices, but further research is needed to explore the relationship between change responses and various implementation constructs.

The study also points to the importance of the “timing” of implementing evidence-based practices, i.e., when implementation occurs. While lack of time is described as a barrier in many implementation studies and determinant frameworks (e.g., [61,62,63]), the temporality of implementation in relation to other changes seems neglected despite the fact that health care professionals usually face many concurrent changes of relevance for their work. Further, implementation studies typically investigate one change, i.e., one evidence-based practice, at a time rather than viewing changes, including those required when implementing evidence-based practices, in a broader perspective of many simultaneous changes.

Conclusion

In conclusion, this study of health care professionals’ change responses identified 10 types of change responses, which could be mapped onto five of the seven response categories of a framework developed by Coetsee [16]. We found that the many changes are met with indifference or passive resistance. Changes are more likely to be accepted if they are initiated by the health care professionals themselves or feature their active input and when changes are well founded and well communicated. This is valuable knowledge for use in the management of changes and for efforts to achieve more successful implementation of evidence-based practices in health care.

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Acknowledgements

The authors would like to thank all the participating physicians, registered nurses, and assistant nurses who participated in the interviews.

Funding

The project was funded by Linköping University.

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

Author information

Authors and Affiliations

Authors

Contributions

PN conceived the study with assistance from the other authors. PN, CE, IS, and KS carried out the interviews, with SB acting as an advisor. PN was responsible for the initial draft of the manuscript. PN was responsible for the initial coding of the data, but further analysis was conducted in close collaboration among all authors. All authors reviewed the final manuscript and provided critical commentary. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Per Nilsen.

Ethics declarations

Ethics approval and consent to participate

The study was approved by the Local Ethics committee in Linköping, Sweden, Dnr: 2018/112–31. All the participants gave their written and oral consent to participate in the interviews. The study was performed according to World Medical Association Declaration of Helsinki ethical principles for medical research involving human subjects. To maintain the principle of non-maleficence, the participants were guaranteed confidentiality, which was taken into account when reporting the findings through abstracted findings presented at the group level. In accordance with respecting the participants’ autonomy, all the participants were informed that they had the right to withdraw from the project at any time without suffering any consequences for their future care. In the interviews, the researchers were aware of power issues, in that an interview is not a conversation between two equal individuals. The interview time was taken into careful consideration. The participants were given the opportunity to reflect on what they said in the interviews, and time was also available for the participants to ask questions.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Nilsen, P., Schildmeijer, K., Ericsson, C. et al. Implementation of change in health care in Sweden: a qualitative study of professionals’ change responses. Implementation Sci 14, 51 (2019). https://0-doi-org.brum.beds.ac.uk/10.1186/s13012-019-0902-6

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