Antifungal Mechanism of Hinokitiol against Candida albicans

Nami Komaki; Toshihiko Watanabe; Ayako Ogasawara; Norifumi Sato; Takeshi Mikami; Tatsuji Matsumoto

doi:10.1248/bpb.31.735

Notes

Antifungal Mechanism of Hinokitiol against Candida albicans

Nami Komaki, Toshihiko Watanabe, Ayako Ogasawara, Norifumi Sato, Takeshi Mikami, Tatsuji Matsumoto

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Keywords: Candida albicans, hinokitiol, ATP, adenylate cyclase (CYR1), RAS1

JOURNAL FREE ACCESS

2008 Volume 31 Issue 4 Pages 735-737

DOI https://doi.org/10.1248/bpb.31.735

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Abstract

The growth of Candida albicans was dose-dependently inhibited by addition of hinokitiol. The sensitivity of C. albicans to hinokitiol under aerobic conditions was higher than that under anaerobic conditions. Amount of ATP in C. albicans was not inhibited by hinokitiol under both conditions. The expression of mRNAs related to the growth signal, CYR1 and RAS1, was inhibited by hinokitiol. These findings suggested that the growth inhibition of C. albicans by hinokitiol was due to the interruption of RAS-signal transmission, such as the cAMP pathway.

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