Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Polyphenols from Eriobotrya japonica and Their Cytotoxicity against Human Oral Tumor Cell Lines
Hideyuki ITOEri KOBAYASHIYoshie TAKAMATSUShu-Hua LITsutomu HATANOHiroshi SAKAGAMIKaoru KUSAMAKazue SATOHDaigo SUGITASusumu SHIMURAYoshio ITOHTakashi YOSHIDA
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2000 Volume 48 Issue 5 Pages 687-693

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Abstract

Three new flavonoid glycosides, togethr with 15 known flavonoids, have been isolated from the leaves of Eriobotrya japonica, and characterized as (2S)- and (2R)-naringenin 8-C-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosides, and cinchonain Id 7-O-β-D-glucopyranoside, respectively, based on spectral analyses including two dimensional (2D) NMR techniques. Higher proanthocyanidin fraction in the water-soluble portion of the extract was characterized as a procyanidin oligomer mixture mainly composed of undecameric procyanidin. These polyphenols have also been assessed for cytotoxic activity against two human oral tumor (human squamous cell carcinoma and human salivary gland tumor) cell lines. Selective cytotoxicity of the procyanidin oligomer between tumor and normal gingival fibroblast cells, and its possible mechanism, were also described.

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© The Pharmaceutical Society of Japan
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