Anti-diabetes Effect of Zn(II)/Carnitine Complex by Oral Administration

Yutaka Yoshikawa; Eriko Ueda; Hiromu Sakurai; Yoshitane Kojima

doi:10.1248/cpb.51.230

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Anti-diabetes Effect of Zn(II)/Carnitine Complex by Oral Administration

Yutaka Yoshikawa, Eriko Ueda, Hiromu Sakurai, Yoshitane Kojima

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Keywords: zinc(II) complex, L-carnitine, hypoglycemic effect, glucose tolerance test, type 2 diabetes, oral administration

JOURNAL FREE ACCESS

2003 Volume 51 Issue 2 Pages 230-231

DOI https://doi.org/10.1248/cpb.51.230

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Abstract

A novel bis(L-carnitinato)Zn(II) complex, Zn(car)₂Cl₂, was prepared, and its insulinomimetic and antidiabetic activities were examined. The complex showed a tendency to lower the high blood glucose levels of KK-A^y mice with type 2 diabetes mellitus when given by oral administration at a dose of 20 mg Zn/kg body weight for 16 d. In addition, the complex improved glucose tolerance ability when examined by the oral glucose tolerance test (1 g glucose/kg body weight).

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