Littorachalcone, a New Enhancer of NGF-Mediated Neurite Outgrowth, from Verbena littoralis

Yushan Li; Masami Ishibashi; Xigui Chen; Yasushi Ohizumi

doi:10.1248/cpb.51.872

Notes

Littorachalcone, a New Enhancer of NGF-Mediated Neurite Outgrowth, from Verbena littoralis

Yushan Li, Masami Ishibashi, Xigui Chen, Yasushi Ohizumi

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Keywords: Verbena littoralis, dihydrochalcone dimer, littorachalcone, nerve growth factor-action, PC12D cell

JOURNAL FREE ACCESS

2003 Volume 51 Issue 7 Pages 872-874

DOI https://doi.org/10.1248/cpb.51.872

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Abstract

A new dihydrochalcone dimer, 2′,4′,3″,2′′′,4′′′-pentahydroxy-4-O-4″-tetrahydrobichalcone, given the name littorachalcone, was isolated from the aerial parts of Verbena littoralis H. B. K. along with two known flavonoids 4′-hydroxywogonin and 8,3′-dimethoxy-5,7,4′-trihydroxyflavone. Littorachalcone caused a significant enhancement of nerve growth factor-mediated neurite outgrowth from PC12D cells.

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