YAKUGAKU ZASSHI
Online ISSN : 1347-5231
Print ISSN : 0031-6903
ISSN-L : 0031-6903
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DPPH Radical-scavenging Effect of Several Phenylpropanoid Compounds and Their Glycoside Derivatives
Hitoshi TOMINAGAYuka KOBAYASHITakashi GOTOKazuo KASEMURAMasato NOMURA
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2005 Volume 125 Issue 4 Pages 371-375

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Abstract

  Eugenol, isoeugenol, caffeic acid, ferulic acid, isoferulic acid, estragole, trans-anethole, and paeonol are components of a Chinese herbal medicine used as a painkiller and stomachic. We investigated the potential role of these compounds as antioxidants. We studied the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical-scavenging effect of these molecules, together with some glycoside derivatives, to ascertain their potential in reducing the levels of activated oxygen species in vivo. The DPPH radical-scavenging effects of eugenol, isoeugenol, and the glycoside derivatives of caffeic acid, ferulic acid, and isoferulic acid (SC50=8—28 μM) were similar to those of α-tocopherol, which was used as a positive control.

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© 2005 by the PHARMACEUTICAL SOCIETY OF JAPAN
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