INDUCER-SPECIFIC REGULATORS OF TUMOR NECROSIS FACTOR ALPHA PRODUCTION

Hiroyuki MIYACHI; Akihiko AZUMA; Erika HIOKI; Yoshiro KOBAYASHI; Shigeo IWASAKI; Yuichi HASHIMOTO

doi:10.1248/cpb.44.1980

Hiroyuki MIYACHI, Akihiko AZUMA, Erika HIOKI, Yoshiro KOBAYASHI, Shigeo IWASAKI, Yuichi HASHIMOTO

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Keywords: tumor necrosis factor, HL-60, phorbol ester, okadaic acid

JOURNAL FREE ACCESS

1996 Volume 44 Issue 10 Pages 1980-1982

DOI https://doi.org/10.1248/cpb.44.1980

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Abstract

Novel potent regulators of tumor necrosis factor alpha (TNF-α) production by a human promyelocytic leukemia cell line, HL-60, were prepared. All the compounds showed inducer-specific and bidirectional regulation of TNF-α production, i.e., they enhanced 12-O-tetradecanoylphorbol-13-acetate-induced TNF-α production, while they inhibited okadaic acid-induced one.

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