Cucurbitane Glycosides from Unripe Fruits of Siraitia grosvenori

Dianpeng Li; Tsuyoshi Ikeda; Toshihiro Nohara; Jinlei Liu; Yongxin Wen; Tatsunori Sakamoto; Gen-Ichiro Nonaka

doi:10.1248/cpb.55.1082

Notes

Cucurbitane Glycosides from Unripe Fruits of Siraitia grosvenori

Dianpeng Li, Tsuyoshi Ikeda, Toshihiro Nohara, Jinlei Liu, Yongxin Wen, Tatsunori Sakamoto, Gen-Ichiro Nonaka

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Keywords: Siraitia grosvenori, Lo Han Kuo, cucurbitane-glycoside, unripe fruit, cytotoxic activity

JOURNAL FREE ACCESS

2007 Volume 55 Issue 7 Pages 1082-1086

DOI https://doi.org/10.1248/cpb.55.1082

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Abstract

Studies on the constituents of the unripe fruits of Siraitia grosvenori led to the isolation of three new cucurbitane triterpene glycosides, 11-oxomogroside III (10), 11-dehydroxymogroside III (11), and 11-oxomogroside IV A (12). Their structures were determined on the basis of detailed analyses of 1D, 2D-NMR spectroscopic methods. All of the compounds isolated from the unripe fruits of S. grosvenori were tested for cytotoxic activities against tumor cells, HCT-116 and SMMC-7721.

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