Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Regular Articles
Synthesis of New N-Analogous Corollosporine Derivatives with Antibacterial Activity by Laccase-Catalyzed Amination
Annett Mikolasch, Susanne Hessel, Manuela Gesell Salazar, Helfried Neumann, Katrin Manda, Dirk Gōrdes, Enrico Schmidt, Kerstin Thurow, Elke Hammer, Ulrike Lindequist, Matthias Beller, Frieder Schauer
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Keywords: corollosporine, laccase, Corollospora maritima, biotransformation, resistance
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2008 Volume 56 Issue 6 Pages 781-786

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Abstract

Corollosporine isolated from the marine fungus Corollospora maritima and N-analogous corollosporines are antimicrobial substances. Owing to the basic structure of the N-analogous corollosporines, they have become an attractive target for laccase-catalyzed derivatisation. In this regard we report on the straightforward laccase-catalyzed amination of dihydroxylated arenes with N-analogous corollosporines. In biological assays the obtained amination products are more active than the parent compounds.

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© 2008 The Pharmaceutical Society of Japan
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