Absolute Stereostructures of Olibanumols A, B, C, H, I, and J from Olibanum, Gum-Resin of Boswellia carterii, and Inhibitors of Nitric Oxide Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages

Masayuki Yoshikawa; Toshio Morikawa; Hideo Oominami; Hisashi Matsuda

doi:10.1248/cpb.57.957

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Absolute Stereostructures of Olibanumols A, B, C, H, I, and J from Olibanum, Gum-Resin of Boswellia carterii, and Inhibitors of Nitric Oxide Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages

Masayuki Yoshikawa, Toshio Morikawa, Hideo Oominami, Hisashi Matsuda

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Keywords: olibanumol, olibanum, Boswellia carterii, monoterpene, triterpene, nitric oxide production inhibitory activity

JOURNAL FREE ACCESS

2009 Volume 57 Issue 9 Pages 957-964

DOI https://doi.org/10.1248/cpb.57.957

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Abstract

Three new monoterpenes, olibanumols A (1), B (2), and C (3), and three new triterpenes, olibanumols H (4), I (5), and J (6), were isolated from olibanum, the exuded gum-resin from Boswellia carterii BIRDW. Their structures including the absolute configuration were determined by chemical and physicochemical evidence. Among the constituents, olibanumols A (1), H (4), and I (5), and isofouquierol (12) exhibited nitric oxide production inhibitory activity in lipopolysaccharide-activated mouse peritoneal macrophages.

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