Plastoquinones from Sargassum yezoense; Chemical Structures and Effects on the Activation of Peroxisome Proliferator-Activated Receptor Gamma

Min Cheol Kim; Hak Cheol Kwon; Su Nam Kim; Hyung Seop Kim; Byung Hun Um

doi:10.1248/cpb.59.834

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Plastoquinones from Sargassum yezoense; Chemical Structures and Effects on the Activation of Peroxisome Proliferator-Activated Receptor Gamma

Min Cheol Kim, Hak Cheol Kwon, Su Nam Kim, Hyung Seop Kim, Byung Hun Um

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Keywords: Sargassum yezoense, plastozuinone, peroxisome proliferator-activated receptor gamma agonist, Brown algae, Sargassacea

JOURNAL FREE ACCESS

2011 Volume 59 Issue 7 Pages 834-838

DOI https://doi.org/10.1248/cpb.59.834

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Abstract

Four new plastoquinones, together with two known compounds, sargahydroquinoic acid and sargaquinoic acid, were isolated from the brown alga, Sargassum yezoense collected from the eastern coast of Korea. The structures of these compounds were elucidated based on spectroscopic analyses including NMR and MS. Their structures designated as meroterphenol A (1), B (2), C (3) and D (4) were characterized by a 6-methyl-1,4-benzohydroquinone moiety with an oxygenated diterpenoic acid chain. Meroterphenols A—D showed potent activation effects on peroxisome proliferator-activated receptor gamma (PPARγ).

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