Clinical Significance of High-Molecular Weight Form of Adiponectin in Male Patients With Coronary Artery Disease

Noriyuki Komura; Shinji Kihara; Mina Sonoda; Masahiro Kumada; Koichi Fujita; Aki Hiuge; Takuya Okada; Yasuhiko Nakagawa; Sachiko Tamba; Yohei Kuroda; Noriyuki Hayashi; Satoru Sumitsuji; Toshiharu Kawamoto; Satoru Matsumoto; Noriyuki Ouchi; Yukio Arita; Yoshihisa Okamoto; Iichiro Shimomura; Tohru Funahashi; Yuji Matsuzawa; The Osaka CAD Group

doi:10.1253/circj.72.23

Clinical Investigation

Clinical Significance of High-Molecular Weight Form of Adiponectin in Male Patients With Coronary Artery Disease

Noriyuki Komura, Shinji Kihara, Mina Sonoda, Masahiro Kumada, Koichi Fujita, Aki Hiuge, Takuya Okada, Yasuhiko Nakagawa, Sachiko Tamba, Yohei Kuroda, Noriyuki Hayashi, Satoru Sumitsuji, Toshiharu Kawamoto, Satoru Matsumoto, Noriyuki Ouchi, Yukio Arita, Yoshihisa Okamoto, Iichiro Shimomura, Tohru Funahashi, Yuji Matsuzawa, The Osaka CAD Group

Author information

Noriyuki Komura
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Shinji Kihara
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Mina Sonoda
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Masahiro Kumada
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Koichi Fujita
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Aki Hiuge
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Takuya Okada
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Yasuhiko Nakagawa
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Sachiko Tamba
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Yohei Kuroda
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Noriyuki Hayashi
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Satoru Sumitsuji
Department of Cardiology, Tokushukai Nozaki Hospital
Toshiharu Kawamoto
Department of Cardiology, National Hospital Organization Kure Medical Center
Satoru Matsumoto
Toyonaka Municipal Hospital
Noriyuki Ouchi
Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine
Yukio Arita
Department of Cardiology, Sumitomo Hospital
Yoshihisa Okamoto
Department of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School
Iichiro Shimomura
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Tohru Funahashi
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University
Yuji Matsuzawa
Department of Cardiology, Sumitomo Hospital
The Osaka CAD Group

Keywords: Coronary artery disease, High molecular weight adiponectin, Metabolic syndrome

JOURNAL FREE ACCESS

2008 Volume 72 Issue 1 Pages 23-28

DOI https://doi.org/10.1253/circj.72.23

J-STAGE : circj 72 3 pp.508-508

Details

Abstract

Background It has been reported previously that the measurement of plasma total adiponectin level is clinically useful to estimate the risk of coronary artery disease (CAD). Here, the relevance of high molecular weight (HMW) adiponectin with risk factors for atherosclerosis is investigated Methods and Results A total of 186 consecutive male CAD patients participated in the study and were categorized into quartiles based on their total adiponectin level. The interquartile cut-off points were 4.0, 5.5 and 7.0 μg/ml. The HMW adiponectin levels were significantly lower in the quartile of lower total adiponectin levels both in non-diabetic and diabetic patients. In contrast, low molecular weight adiponectin levels (which were calculated as the Total - HMW) were constant. In univariate analysis, total adiponectin correlated negatively with body mass index and hemoglobin (Hb) A_1c, and HMW adiponectin correlated negatively with HbA_1c in non-diabetic patients. On the other hand, total and HMW adiponectin correlated positively with high-density lipoprotein-cholesterol (HDL-C) in diabetic patients. Multiple regression analysis revealed that HMW adiponectin correlated negatively with HbA_1c in non-diabetic patients, and total and HMW adiponectin correlated positively with HDL-C in diabetic patients. Conclusions Change in the HMW isoform reflects a change in total adiponectin level. Measurement of total and HMW adiponectin were equally useful in assessing metabolic risk in CAD patients. (Circ J 2008; 72: 23 - 28)

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