Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Ischemic Heart Disease
Relationship Between Coronary Arterial Remodeling, Fibrous Cap Thickness and High-Sensitivity C-Reactive Protein Levels in Patients With Acute Coronary Syndrome
Manabu Kashiwagi, Atsushi Tanaka, Hironori Kitabata, Hiroto Tsujioka, Hiroki Matsumoto, Yu Arita, Keishi Ookochi, Akio Kuroi, Hideaki Kataiwa, Takashi Tanimoto, Hideyuki Ikejima, Shigeho Takarada, Takashi Kubo, Kumiko Hirata, Nobuo Nakamura, Masato Mizukoshi, Toshio Imanishi, Takashi Akasaka
Author information
Keywords: Acute coronary syndrome, Acute myocardial infarction, Remodeling
JOURNAL FREE ACCESS

2009 Volume 73 Issue 7 Pages 1291-1295

View "Advance Publication" version (May 12, 2009).
Details
Download PDF (380K)
Download citation RIS

(compatible with EndNote, Reference Manager, ProCite, RefWorks)

BIB TEX

(compatible with BibDesk, LaTeX)

Text
How to download citation
Contact us
Abstract

Background: Thin-capped fibroatheroma (TCFA) is a recognized precursor lesion for acute coronary syndrome (ACS). Positive remodeling (PR) is the predominant pattern of arterial remodeling in patients with ACS. The aim of this study was to evaluate the relationship between coronary arterial remodeling, fibrous cap thickness and high-sensitivity C-reactive protein (hs-CRP) concentration in patients with ACS. Methods and Results: The 47 consecutive ACS patients were enrolled in this study. Arterial remodeling of culprit plaque was assessed by intravascular ultrasound, and fibrous cap thickness was measured by optical coherence tomography. The remodeling index (RI) was calculated as lesion divided by the reference external elastic membrane cross-sectional area, and PR was defined as RI >1.05 (PR group). TCFA were observed more frequently in the PR group than in the intermediate and negative remodeling (IR/NR) groups (59% vs 17%, P<0.01). RI was inversely correlated with fibrous cap thickness (r=0.47, P=0.02). hs-CRP levels were higher in the PR group than in the IR/NR groups (0.32 ±0.26 vs 0.18 ±0.14 mg/dl, P=0.02). Conclusions: Coronary arterial remodeling, fibrous cap thickness and hs-CRP level in patients with ACS are associated with each other. This result suggests that inflammation simultaneously contributes to both plaque growth and plaque instability. (Circ J 2009; 73: 1291-1295)

Content from these authors
© 2009 THE JAPANESE CIRCULATION SOCIETY
Previous article Next article
Favorites & Alerts

Recently viewed articles
Predecessor

The Nippon Journal of Clinical Angio-Cardiology

Japanese Circulation Journal

JAPANESE CIRCULATION JOURNAL

Related information

Request a Permission

Related journals
Circulation Reports
Share this page
feedback
 Top