Association Between Circulating Monocyte Subsets and In-Stent Restenosis After Coronary Stent Implantation in Patients With ST-Elevation Myocardial Infarction

Yong Liu; Toshio Imanishi; Hideyuki Ikejima; Hiroto Tsujioka; Yuichi Ozaki; Akio Kuroi; Keishi Okochi; Kohei Ishibashi; Takashi Tanimoto; Yasushi Ino; Hironori Kitabata; Takashi Akasaka

doi:10.1253/circj.CJ-10-0544

Cardiovascular Intervention

Association Between Circulating Monocyte Subsets and In-Stent Restenosis After Coronary Stent Implantation in Patients With ST-Elevation Myocardial Infarction

Yong Liu, Toshio Imanishi, Hideyuki Ikejima, Hiroto Tsujioka, Yuichi Ozaki, Akio Kuroi, Keishi Okochi, Kohei Ishibashi, Takashi Tanimoto, Yasushi Ino, Hironori Kitabata, Takashi Akasaka

Author information

Yong Liu
Department of Cardiovascular Medicine, Wakayama Medical University
Toshio Imanishi
Department of Cardiovascular Medicine, Wakayama Medical University
Hideyuki Ikejima
Department of Cardiovascular Medicine, Wakayama Medical University
Hiroto Tsujioka
Department of Cardiovascular Medicine, Wakayama Medical University
Yuichi Ozaki
Department of Cardiovascular Medicine, Wakayama Medical University
Akio Kuroi
Department of Cardiovascular Medicine, Wakayama Medical University
Keishi Okochi
Department of Cardiovascular Medicine, Wakayama Medical University
Kohei Ishibashi
Department of Cardiovascular Medicine, Wakayama Medical University
Takashi Tanimoto
Department of Cardiovascular Medicine, Wakayama Medical University
Yasushi Ino
Department of Cardiovascular Medicine, Wakayama Medical University
Hironori Kitabata
Department of Cardiovascular Medicine, Wakayama Medical University
Takashi Akasaka
Department of Cardiovascular Medicine, Wakayama Medical University

Keywords: Acute myocardial infarction, In-stent restenosis, Monocyte subset

JOURNAL FREE ACCESS

2010 Volume 74 Issue 12 Pages 2585-2591

DOI https://doi.org/10.1253/circj.CJ-10-0544

View "Advance Publication" version (October 7, 2010).

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Abstract

Background: Recent studies have shown that monocytes in human peripheral blood are heterogeneous. The clinical significance of 2 distinct monocyte subsets as a marker of late in-stent restenosis (ISR) following implantation of bare-metal stents (BMSs) in patients with acute myocardial infarction (AMI) was examined. Methods and Results: Seventy-one consecutive patients with AMI who underwent BMS implantation were enrolled in the study. Peripheral blood was collected 12 days after AMI onset. Two distinct monocyte subsets (CD14⁺CD16^-CCR2⁺ and CD14⁺CD16⁺CX3CR1⁺) were measured by flow cytometry. All patients underwent angiography at a scheduled follow up after 9 months. CD14⁺CD16⁺CX3CR1⁺ monocyte subset counts were significantly higher in patients with restenosis than in patients without restenosis, whereas neither the total monocytes nor the CD14⁺CD16^-CCR2⁺ subset counts differed significantly between the 2 groups of patients. There was also a significant positive correlation between the CD14⁺CD16⁺CX3CR1⁺ monocyte counts and angiographic late lumen loss. In multivariate analysis, the CD14⁺CD16⁺CX3CR1⁺ monocyte count was an independent predictor for in-stent late lumen loss. Conclusions: CD14⁺CD16⁺CX3CR1⁺ monocytes might have a role in ISR following coronary BMS implantation in patients with AMI. (Circ J 2010; 74: 2585-2591)

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