Plasma Levels of Uridine Correlate With Blood Pressure and Indicators of Myogenic Purine Degradation and Insulin Resistance in Hypertensive Patients

Toshihiro Hamada; Einosuke Mizuta; Kiyotaka Yanagihara; Yasuhiro Kaetsu; Shinobu Sugihara; Kazuhiko Sonoyama; Yasutaka Yamamoto; Masahiko Kato; Osamu Igawa; Chiaki Shigemasa; Taku Inokuchi; Tetsuya Yamamoto; Toshio Shimada; Akira Ohtahara; Haruaki Ninomiya; Ichiro Hisatome

doi:10.1253/circj.71.354

Clinical Investigation

Plasma Levels of Uridine Correlate With Blood Pressure and Indicators of Myogenic Purine Degradation and Insulin Resistance in Hypertensive Patients

Toshihiro Hamada, Einosuke Mizuta, Kiyotaka Yanagihara, Yasuhiro Kaetsu, Shinobu Sugihara, Kazuhiko Sonoyama, Yasutaka Yamamoto, Masahiko Kato, Osamu Igawa, Chiaki Shigemasa, Taku Inokuchi, Tetsuya Yamamoto, Toshio Shimada, Akira Ohtahara, Haruaki Ninomiya, Ichiro Hisatome

Author information

Toshihiro Hamada
Department of Cardiovascular Medicine, Graduate School of Medical Science, Tottori University
Einosuke Mizuta
Department of Cardiovascular Medicine, Graduate School of Medical Science, Tottori University
Kiyotaka Yanagihara
Department of Cardiovascular Medicine, Graduate School of Medical Science, Tottori University
Yasuhiro Kaetsu
Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science
Shinobu Sugihara
Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science
Kazuhiko Sonoyama
Department of Cardiovascular Medicine, Graduate School of Medical Science, Tottori University
Yasutaka Yamamoto
Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science
Masahiko Kato
Department of Cardiovascular Medicine, Graduate School of Medical Science, Tottori University
Osamu Igawa
Department of Cardiovascular Medicine, Graduate School of Medical Science, Tottori University
Chiaki Shigemasa
Department of Cardiovascular Medicine, Graduate School of Medical Science, Tottori University
Taku Inokuchi
Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine
Tetsuya Yamamoto
Division of Endocrinology and Metabolism, Department of Internal Medicine, Hyogo College of Medicine
Toshio Shimada
Division of Cardiovascular Medicine, Department of Internal Medicine, Shimane University Faculty of Medicine
Akira Ohtahara
Department of Cardiology, San-in Rosai Hospital
Haruaki Ninomiya
Department of Neurobiology, Tottori University Faculty of Medicine
Ichiro Hisatome
Department of Genetic Medicine and Regenerative Therapeutics, Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science

Keywords: Insulin resistance, Myogenic purine degradation, Uridine

JOURNAL FREE ACCESS

2007 Volume 71 Issue 3 Pages 354-356

DOI https://doi.org/10.1253/circj.71.354

Details

Abstract

Background The relationship between plasma uridine levels and blood pressure (BP), and indicators of muscular purine degradation and insulin resistance (IR) has been evaluated in hypertensive (HT) patients. Methods and Results In 36 HT patients and 10 normotensive subjects, seated BP was measured, and blood samples were drawn after overnight fast. In 18 of the HT patients, the semi-ischemic forearm test was performed to examine the release of hypoxanthine, ammonium and lactate. Plasma uridine levels were significantly higher than in the normotensive subjects. Fasting plasma insulin levels and homeostasis model assessment of IR correlated with plasma uridine levels in the HT patients. Plasma uridine levels showed a significant correlation with hypoxanthine, ammonia and lactate released from the semi-ischemic exercising muscles of the HT patients. Conclusions Taken together with the positive correlation with indicators of IR, it is suggested that plasma uridine levels in HT are responsible for purine degradation and IR in skeletal muscles. (Circ J 2007; 71: 354 - 356)

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